args passed: '/Applications/foldit.app/Contents/MacOS/Foldit' args used: '/Applications/foldit.app/Contents/MacOS/Foldit' '-resources' 'cmp-resources-2eef38e6ee152935304bce03020ae9d9/resources' '-database' 'cmp-database-9cc626267aa5f6df9bcb5f94584712fd/database' '-interactive_game' 'novice' '-interactive:interactive_residue_types' '-ignore_unrecognized_res' '-ignore_zero_occupancy' 'false' '-in::use_truncated_termini' '-out:levels' 'all:warning' 'interactive:info' 'standalone:info' 'game:info' '-out:no_color' '-load_PDB_components' 'false' interactive.util.options_dict: {0} Loading options file standalone.application.StandaloneViewPresetList: {0} StandaloneViewPresetList->load_preset_files(): successfully loaded view preset files standalone.application.StandaloneViewPresetList: {0} StandaloneViewPresetList->load_preset_files(): successfully loaded view preset files game.application.GameApplication: {0} Initializing game.application.server.CurlFetcher: {0} https://fold.it/api/post_crash_report interactive.sound/SoundTheme: {0} SoundTheme::load: cmp-resources-2eef38e6ee152935304bce03020ae9d9/resources/sounds/organic_01 interactive.sound/SoundTheme: {0} loading: cmp-resources-2eef38e6ee152935304bce03020ae9d9/resources/sounds/organic_01/rotamer_land_00.ogg interactive.sound/SoundTheme: {0} loading: cmp-resources-2eef38e6ee152935304bce03020ae9d9/resources/sounds/organic_01/rotamer_land_01.ogg interactive.sound/SoundTheme: {0} loading: cmp-resources-2eef38e6ee152935304bce03020ae9d9/resources/sounds/organic_01/rotamer_land_02.ogg interactive.sound/SoundTheme: {0} loading: cmp-resources-2eef38e6ee152935304bce03020ae9d9/resources/sounds/organic_01/rotamer_land_03.ogg interactive.sound/SoundTheme: {0} loading: cmp-resources-2eef38e6ee152935304bce03020ae9d9/resources/sounds/organic_01/rotamer_land_04.ogg interactive.sound/SoundTheme: {0} loading: cmp-resources-2eef38e6ee152935304bce03020ae9d9/resources/sounds/organic_01/rotamer_land_05.ogg standalone.application.StandaloneApplication: {0} (@init_machine_log)intro_level_version_ is 0 interactive.util.options_dict: {0} We're loading in the hotkeys interactive.util.options_dict: {0} We loaded in the hotkeys interactive.rosetta_util.ExposedHydrophobicsCalculator: {0} SVM classifier successfully loaded interactive.rosetta_util.ExposedHydrophobicsCalculator: {0} Feature list successfully loaded interactive.rosetta_util.ExposedHydrophobicsCalculator: {0} Valid classifier feature list interactive.remote.RemoteThread: {0} REMOTE Local Address: 192.168.86.29 standalone.application.StandaloneApplication: {0} about to create view_options_button_ interactive.application.shared.ToolApplication: {0} setting side chain mode to: 1 Show Stubs interactive.remote.RemoteDialog: {0} Found remote enable option: 0 game.application.AlphaFoldDialog: {0} POS UDim< rel:0 abs:345 self:0 >:UDim< rel:0 abs:-6 self:0 > game.application.server.Updater: {0} checking updates... game.application.server.CurlFetcher: {0} https://fold.it/api/get_update_components game.application.server.Updater: {0} binary game.application.server.Updater: {0} local: 'f02e0613ed3d0314a84804bc4af5e7c6' game.application.server.Updater: {0} remote: 'f02e0613ed3d0314a84804bc4af5e7c6' game.application.server.Updater: {0} database game.application.server.Updater: {0} local: '9cc626267aa5f6df9bcb5f94584712fd' game.application.server.Updater: {0} remote: '9cc626267aa5f6df9bcb5f94584712fd' game.application.server.Updater: {0} resources game.application.server.Updater: {0} local: '2eef38e6ee152935304bce03020ae9d9' game.application.server.Updater: {0} remote: '2eef38e6ee152935304bce03020ae9d9' game.application.server.Updater: {0} cleaning up old components: game.application.server.Updater: {0} database 9cc626267aa5f6df9bcb5f94584712fd game.application.server.Updater: {0} resources 2eef38e6ee152935304bce03020ae9d9 game.application.server.Updater: {0} binary f02e0613ed3d0314a84804bc4af5e7c6 game.application.server.CurlFetcher: {0} https://fold.it/api/get_news standalone.application.StandaloneApplication: {0} Show splash! standalone.application.StandaloneApplication: {0} Playing: sounds/organic_01/splashscreen.ogg standalone.application.StandaloneApplication: {0} Converting any old-style quicksaves and autosaves... standalone.application.GeneralOptionsPanel: {0} buildid: V25-20230510-4bc8a4b03b-macos_x64-devprev game.application.GameApplication: {0} Ended pre-login init game.application.server.CurlFetcher: {0} https://fold.it/api/get_user_info game.application.GameApplication: {0} Logged in with player ID: 172532 game.application.server.CurlFetcher: {0} https://fold.it/api/get_user_info game.application.server.CurlFetcher: {0} https://fold.it/api/get_puzzles standalone.application.boinc.Puzzle: {0} .ocmdline d0c38b589470b99976db250c17c71d3d standalone.application.boinc.Puzzle: {0} .ofilters eb8c2fc8a467c4cf237618a29c45f665 standalone.application.boinc.Puzzle: {0} .opdb a7916996dc6adb777c51f4c4a575fa84 standalone.application.boinc.Puzzle: {0} .opuzzle_setup eddf1be56eb7d97f3a0ce625e923bff7 standalone.application.boinc.Puzzle: {0} .owts d2f7165a0e0f8d0203c093ba8d54267f standalone.application.boinc.Puzzle: {0} .opdb 2cb8ff8457d30a4bf7f2ba9e4df53760 standalone.application.boinc.Puzzle: {0} .opuzzle_setup 9090234d1eabcc31aeb31cc118fa57e2 standalone.application.boinc.Puzzle: {0} .owts d2f7165a0e0f8d0203c093ba8d54267f standalone.application.boinc.Puzzle: {0} .odensity 0ec96a8677ee654aeb9f398c35788c9a standalone.application.boinc.Puzzle: {0} .opdb 8cb39d7c3c76080f0ce3b66d76485633 standalone.application.boinc.Puzzle: {0} .opuzzle_setup d8f3716eaf7d2d2878c34987b34c8ae4 standalone.application.boinc.Puzzle: {0} .owts d2f7165a0e0f8d0203c093ba8d54267f standalone.application.boinc.Puzzle: {0} .owts_patch b492b64225a26b2b882d56da3585b00a standalone.application.boinc.Puzzle: {0} .ocmdline e14ffdcac91bac948806a2ff7ed87ea4 standalone.application.boinc.Puzzle: {0} .opdb baf2b55ed9d608eccf6b6b91dac460d3 standalone.application.boinc.Puzzle: {0} .opuzzle_setup 55ebdc3066184544e214ab59b3e564d6 standalone.application.boinc.Puzzle: {0} .owts d2f7165a0e0f8d0203c093ba8d54267f standalone.application.boinc.Puzzle: {0} .sym 9416a20b4855d4d4b0754de653e7dd55 standalone.application.boinc.Puzzle: {0} .ocmdline 9213d67f559515a2b1c07bd45bdb7cf9 standalone.application.boinc.Puzzle: {0} .ocnstr adee7993ef58481848b77be273ca0301 standalone.application.boinc.Puzzle: {0} .ofilters 7ac1df082f19ea354c52ff327c3f8072 standalone.application.boinc.Puzzle: {0} .opdb 16436660143808fe77ad2b2d3c6db17b standalone.application.boinc.Puzzle: {0} .opuzzle_setup 63dc36329331e9ebb264d652e4aa7668 standalone.application.boinc.Puzzle: {0} .owts d2f7165a0e0f8d0203c093ba8d54267f standalone.application.boinc.Puzzle: {0} .opdb 2cb8ff8457d30a4bf7f2ba9e4df53760 standalone.application.boinc.Puzzle: {0} .opuzzle_setup 9090234d1eabcc31aeb31cc118fa57e2 standalone.application.boinc.Puzzle: {0} .owts d2f7165a0e0f8d0203c093ba8d54267f standalone.application.boinc.Puzzle: {0} .odensity e5f5f3378cecc44214c2af590b6c69c6 standalone.application.boinc.Puzzle: {0} .opdb 2ff8adf0e898fe11e42ed04f7fec6761 standalone.application.boinc.Puzzle: {0} .opuzzle_setup beba35efb5c3dc08b28f827c509250d8 standalone.application.boinc.Puzzle: {0} .owts 176403f366c9d25492c31b94f83a88c2 standalone.application.boinc.Puzzle: {0} .opdb c6490826114e5dcc37b91036f4690dd5 standalone.application.boinc.Puzzle: {0} .opuzzle_setup 08586216d9939ed1b557037a98b94cc2 standalone.application.boinc.Puzzle: {0} .owts 5b16284e5e5e4f85b6793eba788a0ce0 standalone.application.boinc.Puzzle: {0} .opdb 54dba4dcebad32bcdde53965ccb21607 standalone.application.boinc.Puzzle: {0} .opuzzle_setup 0cf734fcccc42fbe2f314ba6a61438d3 standalone.application.boinc.Puzzle: {0} .owts d2f7165a0e0f8d0203c093ba8d54267f standalone.application.boinc.Puzzle: {0} .ofilters 3790bcec7e10552b902b30d71d696907 standalone.application.boinc.Puzzle: {0} .opdb 69d2dbeb70617bf3b36a4d7ad3f48423 standalone.application.boinc.Puzzle: {0} .opuzzle_setup 42536dca75676873cb510df315ab6b83 standalone.application.boinc.Puzzle: {0} .owts b4fb927e049837a8d522d1bf29e015ee standalone.application.boinc.Puzzle: {0} .params 0f190c11bb73cebfd0baf037c6bbd65a game.application.server.CurlFetcher: {0} https://fold.it/api/get_puzzle_scores game.application.server.CurlFetcher: {0} https://fold.it/api/get_puzzle_scores game.application.server.CurlFetcher: {0} https://fold.it/api/get_puzzle_scores game.application.server.CurlFetcher: {0} https://fold.it/api/get_puzzle_scores game.application.server.CurlFetcher: {0} https://fold.it/api/get_puzzle_scores game.application.server.CurlFetcher: {0} https://fold.it/api/get_puzzle_scores game.application.server.CurlFetcher: {0} https://fold.it/api/get_puzzle_scores game.application.server.CurlFetcher: {0} https://fold.it/api/get_puzzle_scores game.application.server.CurlFetcher: {0} https://fold.it/api/get_puzzle_scores game.application.server.CurlFetcher: {0} https://fold.it/api/get_puzzle_scores game.application.server.CurlFetcher: {0} https://fold.it/api/get_puzzles standalone.application.boinc.Puzzle: {0} .ocmdline d0c38b589470b99976db250c17c71d3d standalone.application.boinc.Puzzle: {0} .ofilters eb8c2fc8a467c4cf237618a29c45f665 standalone.application.boinc.Puzzle: {0} .opdb a7916996dc6adb777c51f4c4a575fa84 standalone.application.boinc.Puzzle: {0} .opuzzle_setup eddf1be56eb7d97f3a0ce625e923bff7 standalone.application.boinc.Puzzle: {0} .owts d2f7165a0e0f8d0203c093ba8d54267f standalone.application.boinc.Puzzle: {0} .opdb 2cb8ff8457d30a4bf7f2ba9e4df53760 standalone.application.boinc.Puzzle: {0} .opuzzle_setup 9090234d1eabcc31aeb31cc118fa57e2 standalone.application.boinc.Puzzle: {0} .owts d2f7165a0e0f8d0203c093ba8d54267f standalone.application.boinc.Puzzle: {0} .odensity 0ec96a8677ee654aeb9f398c35788c9a standalone.application.boinc.Puzzle: {0} .opdb 8cb39d7c3c76080f0ce3b66d76485633 standalone.application.boinc.Puzzle: {0} .opuzzle_setup d8f3716eaf7d2d2878c34987b34c8ae4 standalone.application.boinc.Puzzle: {0} .owts d2f7165a0e0f8d0203c093ba8d54267f standalone.application.boinc.Puzzle: {0} .owts_patch b492b64225a26b2b882d56da3585b00a standalone.application.boinc.Puzzle: {0} .ocmdline e14ffdcac91bac948806a2ff7ed87ea4 standalone.application.boinc.Puzzle: {0} .opdb baf2b55ed9d608eccf6b6b91dac460d3 standalone.application.boinc.Puzzle: {0} .opuzzle_setup 55ebdc3066184544e214ab59b3e564d6 standalone.application.boinc.Puzzle: {0} .owts d2f7165a0e0f8d0203c093ba8d54267f standalone.application.boinc.Puzzle: {0} .sym 9416a20b4855d4d4b0754de653e7dd55 standalone.application.boinc.Puzzle: {0} .ocmdline 9213d67f559515a2b1c07bd45bdb7cf9 standalone.application.boinc.Puzzle: {0} .ocnstr adee7993ef58481848b77be273ca0301 standalone.application.boinc.Puzzle: {0} .ofilters 7ac1df082f19ea354c52ff327c3f8072 standalone.application.boinc.Puzzle: {0} .opdb 16436660143808fe77ad2b2d3c6db17b standalone.application.boinc.Puzzle: {0} .opuzzle_setup 63dc36329331e9ebb264d652e4aa7668 standalone.application.boinc.Puzzle: {0} .owts d2f7165a0e0f8d0203c093ba8d54267f standalone.application.boinc.Puzzle: {0} .opdb 2cb8ff8457d30a4bf7f2ba9e4df53760 standalone.application.boinc.Puzzle: {0} .opuzzle_setup 9090234d1eabcc31aeb31cc118fa57e2 standalone.application.boinc.Puzzle: {0} .owts d2f7165a0e0f8d0203c093ba8d54267f standalone.application.boinc.Puzzle: {0} .odensity e5f5f3378cecc44214c2af590b6c69c6 standalone.application.boinc.Puzzle: {0} .opdb 2ff8adf0e898fe11e42ed04f7fec6761 standalone.application.boinc.Puzzle: {0} .opuzzle_setup beba35efb5c3dc08b28f827c509250d8 standalone.application.boinc.Puzzle: {0} .owts 176403f366c9d25492c31b94f83a88c2 standalone.application.boinc.Puzzle: {0} .opdb c6490826114e5dcc37b91036f4690dd5 standalone.application.boinc.Puzzle: {0} .opuzzle_setup 08586216d9939ed1b557037a98b94cc2 standalone.application.boinc.Puzzle: {0} .owts 5b16284e5e5e4f85b6793eba788a0ce0 standalone.application.boinc.Puzzle: {0} .opdb 54dba4dcebad32bcdde53965ccb21607 standalone.application.boinc.Puzzle: {0} .opuzzle_setup 0cf734fcccc42fbe2f314ba6a61438d3 standalone.application.boinc.Puzzle: {0} .owts d2f7165a0e0f8d0203c093ba8d54267f standalone.application.boinc.Puzzle: {0} .ofilters 3790bcec7e10552b902b30d71d696907 standalone.application.boinc.Puzzle: {0} .opdb 69d2dbeb70617bf3b36a4d7ad3f48423 standalone.application.boinc.Puzzle: {0} .opuzzle_setup 42536dca75676873cb510df315ab6b83 standalone.application.boinc.Puzzle: {0} .owts b4fb927e049837a8d522d1bf29e015ee standalone.application.boinc.Puzzle: {0} .params 0f190c11bb73cebfd0baf037c6bbd65a standalone.application.intro.level_util: {0} JM level version = 0 standalone.application.intro.level_util: {0} Using file: cmp-resources-2eef38e6ee152935304bce03020ae9d9/resources/levels/campaign_2020.intros standalone.application.intro.level_util: {0} Using file: cmp-resources-2eef38e6ee152935304bce03020ae9d9/resources/levels/educational_puzzles.intros standalone.application.intro.level_util: {0} Using file: cmp-resources-2eef38e6ee152935304bce03020ae9d9/resources/levels/endless_puzzles.intros game.application.server.CurlFetcher: {0} https://fold.it/api/get_puzzle_completions game.application.GameApplication: {0} bad file checksums, refreshing from server... game.application.server.CurlFetcher: {0} https://fold.it/api/get_puzzle standalone.application.boinc.Puzzle: {0} .ofilters 3790bcec7e10552b902b30d71d696907 standalone.application.boinc.Puzzle: {0} .opdb 69d2dbeb70617bf3b36a4d7ad3f48423 standalone.application.boinc.Puzzle: {0} .opuzzle_setup 42536dca75676873cb510df315ab6b83 standalone.application.boinc.Puzzle: {0} .owts b4fb927e049837a8d522d1bf29e015ee standalone.application.boinc.Puzzle: {0} .params d38eada029572535f68a6ca3e1d4e132 standalone.application.boinc.Puzzle: {0} has key .owts standalone.application.boinc.Puzzle: {0} has key .params standalone.application.boinc.Puzzle: {0} has key .opdb standalone.application.boinc.Puzzle: {0} has key .opuzzle_setup standalone.application.boinc.Puzzle: {0} has key .ofilters interactive.application.appfilter.LigandSubstructureFilter: {0} Looking for 'cmp-database-9cc626267aa5f6df9bcb5f94584712fd/database/scoring/drug_design/substructure_penalties/c1occc1CC(=O)O.smi' interactive.application.appfilter.LigandSubstructureFilter: {0} Looking for 'cmp-database-9cc626267aa5f6df9bcb5f94584712fd/database/scoring/drug_design/substructure_penalties/bi.smi' interactive.application.appfilter.LigandSubstructureFilter: {0} Looking for 'cmp-database-9cc626267aa5f6df9bcb5f94584712fd/database/scoring/drug_design/substructure_penalties/[#6]=C-O.smi' interactive.application.appfilter.LigandSubstructureFilter: {0} Looking for 'cmp-database-9cc626267aa5f6df9bcb5f94584712fd/database/scoring/drug_design/substructure_penalties/[#6]=C-N.smi' interactive.application.appfilter.LigandSubstructureFilter: {0} Looking for 'cmp-database-9cc626267aa5f6df9bcb5f94584712fd/database/scoring/drug_design/substructure_penalties/[OH]-C-[OH].smi' interactive.application.appfilter.LigandSubstructureFilter: {0} Looking for 'cmp-database-9cc626267aa5f6df9bcb5f94584712fd/database/scoring/drug_design/substructure_penalties/OCC[OH].smi' interactive.application.appfilter.LigandSubstructureFilter: {0} Looking for 'cmp-database-9cc626267aa5f6df9bcb5f94584712fd/database/scoring/drug_design/substructure_penalties/C(=S).smi' interactive.application.appfilter.LigandSubstructureFilter: {0} Looking for 'cmp-database-9cc626267aa5f6df9bcb5f94584712fd/database/scoring/drug_design/substructure_penalties/C=C-C=O.smi' interactive.application.appfilter.LigandSubstructureFilter: {0} Looking for 'cmp-database-9cc626267aa5f6df9bcb5f94584712fd/database/scoring/drug_design/substructure_penalties/N-;!@O.smi' interactive.application.appfilter.LigandSubstructureFilter: {0} Looking for 'cmp-database-9cc626267aa5f6df9bcb5f94584712fd/database/scoring/drug_design/substructure_penalties/N-;!@N.smi' interactive.application.appfilter.LigandSubstructureFilter: {0} Looking for 'cmp-database-9cc626267aa5f6df9bcb5f94584712fd/database/scoring/drug_design/substructure_penalties/N=!@C.smi' interactive.application.appfilter.LigandSubstructureFilter: {0} Looking for 'cmp-database-9cc626267aa5f6df9bcb5f94584712fd/database/scoring/drug_design/substructure_penalties/[!r;C]=[!r;C][!r;C]=[!r;C].smi' interactive.application.appfilter.LigandSubstructureFilter: {0} Looking for 'cmp-database-9cc626267aa5f6df9bcb5f94584712fd/database/scoring/drug_design/substructure_penalties/[!r;C][!r;O]CCC.smi' interactive.application.appfilter.LigandSubstructureFilter: {0} Looking for 'cmp-database-9cc626267aa5f6df9bcb5f94584712fd/database/scoring/drug_design/substructure_penalties/C-!@C-!@C-!@C-!@C.smi' interactive.application.appfilter.LigandSubstructureFilter: {0} Looking for 'cmp-database-9cc626267aa5f6df9bcb5f94584712fd/database/scoring/drug_design/substructure_penalties/[N&!$(N=[*])&!$(N-[*]=[*])&!$(N-[*]:[*])&!$(N#[*])&!$(N-[*]#[*])].smi' interactive.application.appfilter.LigandSubstructureFilter: {0} Looking for 'cmp-database-9cc626267aa5f6df9bcb5f94584712fd/database/scoring/drug_design/substructure_penalties/O=C-O-C.smi' interactive.application.appfilter.LigandSubstructureFilter: {0} Looking for 'cmp-database-9cc626267aa5f6df9bcb5f94584712fd/database/scoring/drug_design/substructure_penalties/[C;!r0&!r5&!r6].smi' interactive.application.appfilter.LigandSubstructureFilter: {0} Looking for 'cmp-database-9cc626267aa5f6df9bcb5f94584712fd/database/scoring/drug_design/substructure_penalties/[c,n;!R1&!R2].smi' interactive.application.appfilter.LigandSubstructureFilter: {0} Looking for 'cmp-database-9cc626267aa5f6df9bcb5f94584712fd/database/scoring/drug_design/substructure_penalties/N-c.N-c.N-c.smi' interactive.application.appfilter.LigandSubstructureFilter: {0} Looking for 'cmp-database-9cc626267aa5f6df9bcb5f94584712fd/database/scoring/drug_design/substructure_penalties/[r4]=[r4].smi' interactive.application.appfilter.LigandSubstructureFilter: {0} Looking for 'cmp-database-9cc626267aa5f6df9bcb5f94584712fd/database/scoring/drug_design/substructure_penalties/a:a:a:a:a:a:a:a:a:a:a.smi' interactive.application.appfilter.LigandSubstructureFilter: {0} Looking for 'cmp-database-9cc626267aa5f6df9bcb5f94584712fd/database/scoring/drug_design/substructure_penalties/[A;H1,H2]1-A=A-A=A1.smi' interactive.application.appfilter.LigandSubstructureFilter: {0} Looking for 'cmp-database-9cc626267aa5f6df9bcb5f94584712fd/database/scoring/drug_design/substructure_penalties/A=A1-A=A-A(=A)-[A;H1,H2]1.smi' interactive.application.appfilter.LigandSubstructureFilter: {0} Looking for 'cmp-database-9cc626267aa5f6df9bcb5f94584712fd/database/scoring/drug_design/substructure_penalties/[C;H1,H2]1-A=A-A(=A)-A=A1.smi' interactive.application.appfilter.LigandSubstructureFilter: {0} Looking for 'cmp-database-9cc626267aa5f6df9bcb5f94584712fd/database/scoring/drug_design/substructure_penalties/[A;H1,H2]1-A=A-A=A-[A;H1,H2]1.smi' interactive.application.appfilter.LigandSubstructureFilter: {0} Looking for 'cmp-database-9cc626267aa5f6df9bcb5f94584712fd/database/scoring/drug_design/substructure_penalties/C#C.C#C.smi' interactive.application.appfilter.LigandSubstructureFilter: {0} Looking for 'cmp-database-9cc626267aa5f6df9bcb5f94584712fd/database/scoring/drug_design/substructure_penalties/N-N.smi' interactive.application.appfilter.LigandSubstructureFilter: {0} Looking for 'cmp-database-9cc626267aa5f6df9bcb5f94584712fd/database/scoring/drug_design/substructure_penalties/[#7].[#7].[#7].[#7].[#7].[#7].smi' interactive.application.appfilter.LigandSubstructureFilter: {0} Looking for 'cmp-database-9cc626267aa5f6df9bcb5f94584712fd/database/scoring/drug_design/substructure_penalties/[#15].smi' interactive.application.appfilter.LigandSubstructureFilter: {0} Looking for 'cmp-database-9cc626267aa5f6df9bcb5f94584712fd/database/scoring/drug_design/substructure_penalties/[#16].[#16].smi' interactive.application.appfilter.LigandSubstructureFilter: {0} Looking for 'cmp-database-9cc626267aa5f6df9bcb5f94584712fd/database/scoring/drug_design/substructure_penalties/[#9].[#9].[#9].[#9].[#9].smi' interactive.application.appfilter.LigandSubstructureFilter: {0} Looking for 'cmp-database-9cc626267aa5f6df9bcb5f94584712fd/database/scoring/drug_design/substructure_penalties/[#17].[#17].[#17].[#17].[#17].smi' interactive.application.appfilter.LigandSubstructureFilter: {0} Looking for 'cmp-database-9cc626267aa5f6df9bcb5f94584712fd/database/scoring/drug_design/substructure_penalties/[#35].[#35].smi' interactive.application.appfilter.LigandSubstructureFilter: {0} Looking for 'cmp-database-9cc626267aa5f6df9bcb5f94584712fd/database/scoring/drug_design/substructure_penalties/[#53].[#53].smi' interactive.rosetta_util.ligand.RareyRotamerLibrary: {0} This software uses the Torsion Library jointly developed by the University of Hamburg, Center for Bioinformatics, Hamburg, Germany and F. Hoffmann-La-Roche Ltd., Basel, Switzerland. interactive.rosetta_util.ligand.RareyRotamerLibrary: {0} Ignoring torsion pattern [CX4:1][CX4H2:2]!@[NX3;"N_lp":3][CX4:4] due to presence of N_lp rule. interactive.rosetta_util.ligand.RareyRotamerLibrary: {0} Ignoring torsion pattern [C:1][CX4H2:2]!@[NX3;"N_lp":3][C:4] due to presence of N_lp rule. interactive.rosetta_util.ligand.RareyRotamerLibrary: {0} Ignoring torsion pattern [C:1][CX4:2]!@[NX3;"N_lp":3][C:4] due to presence of N_lp rule. interactive.rosetta_util.ligand.RareyRotamerLibrary: {0} Ignoring torsion pattern [!#1:1][CX4H2:2]!@[NX3H1;"N_lp":3][!#1:4] due to presence of N_lp rule. interactive.rosetta_util.ligand.RareyRotamerLibrary: {0} Ignoring torsion pattern [!#1:1][CX4H2:2]!@[NX3;"N_lp":3][!#1:4] due to presence of N_lp rule. interactive.rosetta_util.ligand.RareyRotamerLibrary: {0} Ignoring torsion pattern [!#1:1][CX4:2]!@[NX3;"N_lp":3] due to presence of N_lp rule. interactive.rosetta_util.ligand.RareyRotamerLibrary: {0} Ignoring torsion pattern [!#1:1][CX4:2]!@[NX3;"N_lp":3][!#1:4] due to presence of N_lp rule. interactive.rosetta_util.ligand.RareyRotamerLibrary: {0} Ignoring torsion pattern [!#1:1][$(S(=O)=O):2]!@["N_lp":3]@[Cr3] due to presence of N_lp rule. interactive.rosetta_util.ligand.RareyRotamerLibrary: {0} Ignoring torsion pattern [C:1][$(S(=O)=O):2]!@["N_lp":3] due to presence of N_lp rule. interactive.rosetta_util.ligand.RareyRotamerLibrary: {0} Ignoring torsion pattern [c:1][$(S(=O)=O):2]!@["N_lp":3] due to presence of N_lp rule. interactive.rosetta_util.ligand.RareyRotamerLibrary: {0} Ignoring torsion pattern [!#1:1][$(S(=O)=O):2]!@["N_lp":3] due to presence of N_lp rule. standalone.application.boinc.Puzzle: {0} starting score : -1406.54 standalone.application.boinc.Puzzle: {0} puzzle loaded standalone.application.StandaloneApplication: {0} Autosave puzzles/0002013636/0000172532/default/autosave.ir_solution loaded. game.application.GameApplication: {0} Loading puzzle 2013636 standalone.application.StandaloneApplication: {0} Autosave puzzles/0002013636/0000172532/default/autosave-best.ir_solution loaded. standalone.application.StandaloneApplication: {0} Autosave puzzles/0002013636/0000172532/default/autosave-recentbest.ir_solution loaded. standalone.application.StandaloneApplication: {0} Autosave puzzles/0002013636/0000172532/default/autosave-creditbest.ir_solution loaded. standalone.application.StandaloneApplication: {0} Autosave puzzles/0002013636/0000172532/default/autosave-best.ir_solution loaded. standalone.application.StandaloneApplication: {0} Autosave puzzles/0002013636/0000172532/default/autosave-recentbest.ir_solution loaded. standalone.application.StandaloneApplication: {0} Autosave puzzles/0002013636/0000172532/default/autosave-creditbest.ir_solution loaded. standalone.application.StandaloneApplication: {0} Autosave puzzles/0002013636/0000172532/default/autosave-best.ir_solution loaded. standalone.application.StandaloneApplication: {0} Autosave puzzles/0002013636/0000172532/default/autosave-recentbest.ir_solution loaded. standalone.application.StandaloneApplication: {0} Autosave puzzles/0002013636/0000172532/default/autosave-creditbest.ir_solution loaded. interactive.application.actions.loop_hash_utils: {0} building library...interactive.application.actions.loop_hash_utils: {0} done. standalone.application.StandaloneApplication: {0} conditions are enabled standalone.application.TitlePanel: {0} TitlePanel new session standalone.application.ScorePanel: {0} ScorePanel new session standalone.application.ViewOptionsPanelButton: {0} ViewOptionsPanelButton new session standalone.application.HelpPanelButton: {0} HelpPanelButton new session standalone.application.ActionOptionsPanelButton: {0} ActionOptionsPanelButton new session standalone.application.UndoPanelButton: {0} UndoPanelButton new session standalone.application.CookbookPanelButton: {0} CookbookPanelButton new session standalone.application.HamburgerPanelButton: {0} HamburgerPanelButton new session interactive.application.appposeview.ElectronDensityGeom: {0} clear density... game.application.server.PrereleaseDialog: {0} PHASE PRE? : 0 game.application.server.PrereleaseDialog: {0} Normal game.application.server.PrereleaseDialog: {0} PreRelease game.application.server.CurlFetcher: {0} https://fold.it/api/get_solutions game.application.server.CurlFetcher: {0} https://fold.it/api/get_recipes game.application.GameApplication: {0} GROUP CHAT CHANNEL: GoScience game.application.server.CurlFetcher: {0} https://fold.it/api/get_puzzle_scores game.application.server.CurlFetcher: {0} https://fold.it/api/get_irc_server game.application.GameApplication: {0} BOINC says connect to: irc.fold.it:6667 game.application.GameApplication: {0} Using nick: NinjaGreg game.util.IRC: {0} IRC::disconnect game.util.IRC: {0} IRC::connect game.application.GameApplication: {0} Ended Initialization of GameApplication game.util.IRC: {0} IRC::connect connecting game.util.IRC: {0} Entering IRC::run standalone.application.StandaloneApplication: {0} Current Track: Evo1 standalone.application.StandaloneApplication: {0} Autosave puzzles/0002013636/0000172532/Evo1/autosave.ir_solution loaded. game.application.GameApplication: {0} Loading puzzle 2013636 standalone.application.StandaloneApplication: {0} Autosave puzzles/0002013636/0000172532/Evo1/autosave-best.ir_solution loaded. interactive.rosetta_util.ligand.ThreadedRDKitRotamerLibrarySpecification: {0} It took 0.330217s to generate 15 conformers for LG_5002: [H]c1oc([H])c(C([H])([H])C(=O)[O-])c1-c1c([H])c([H])c([H])c(C(=O)N([H])[H])c1[H] standalone.application.StandaloneApplication: {0} Autosave puzzles/0002013636/0000172532/Evo1/autosave-recentbest.ir_solution loaded. standalone.application.StandaloneApplication: {0} Autosave puzzles/0002013636/0000172532/Evo1/autosave-creditbest.ir_solution loaded. game.util.IRC: {0} IRC::run recv error game.util.IRC: {0} Exiting IRC::run standalone.application.StandaloneApplication: {0} Autosave puzzles/0002013636/0000172532/Evo1/autosave-best-improver.ir_solution loaded. standalone.application.StandaloneApplication: {0} Autosave puzzles/0002013636/0000172532/Evo1/autosave-recentbest-improver.ir_solution loaded. standalone.application.StandaloneApplication: {0} Autosave puzzles/0002013636/0000172532/Evo1/autosave-best-improver.ir_solution loaded. standalone.application.StandaloneApplication: {0} Autosave puzzles/0002013636/0000172532/Evo1/autosave-recentbest-improver.ir_solution loaded. standalone.application.StandaloneApplication: {0} Autosave puzzles/0002013636/0000172532/Evo1/autosave-creditbest.ir_solution loaded. interactive.rosetta_util.ligand.ThreadedRDKitRotamerLibrarySpecification: {0} It took 0.334598s to generate 15 conformers for LG_5002: [H]c1oc([H])c(C([H])([H])C(=O)[O-])c1-c1c([H])c([H])c([H])c(C(=O)N([H])[H])c1[H] interactive.rosetta_util.ligand.ThreadedRDKitRotamerLibrarySpecification: {0} It took 0.332038s to generate 15 conformers for LG_5002: [H]c1oc([H])c(C([H])([H])C(=O)[O-])c1-c1c([H])c([H])c([H])c(C(=O)N([H])[H])c1[H] standalone.application.StandaloneApplication: {0} Autosave puzzles/0002013636/0000172532/Evo1/autosave-best-improver.ir_solution loaded. standalone.application.StandaloneApplication: {0} Autosave puzzles/0002013636/0000172532/Evo1/autosave-recentbest-improver.ir_solution loaded. standalone.application.StandaloneApplication: {0} Autosave puzzles/0002013636/0000172532/Evo1/autosave-creditbest.ir_solution loaded. interactive.rosetta_util.ligand.ThreadedRDKitRotamerLibrarySpecification: {0} It took 0.334879s to generate 15 conformers for LG_5002: [H]c1oc([H])c(C([H])([H])C(=O)[O-])c1-c1c([H])c([H])c([H])c(C(=O)N([H])[H])c1[H] interactive.rosetta_util.ligand.ThreadedRDKitRotamerLibrarySpecification: {0} It took 0.325662s to generate 15 conformers for LG_5002: [H]c1oc([H])c(C([H])([H])C(=O)[O-])c1-c1c([H])c([H])c([H])c(C(=O)N([H])[H])c1[H] interactive.rosetta_util.ligand.ThreadedRDKitRotamerLibrarySpecification: {0} It took 0.330648s to generate 15 conformers for LG_5002: [H]c1oc([H])c(C([H])([H])C(=O)[O-])c1-c1c([H])c([H])c([H])c(C(=O)N([H])[H])c1[H] interactive.rosetta_util.ligand.ThreadedRDKitRotamerLibrarySpecification: {0} It took 0.329169s to generate 15 conformers for LG_5002: [H]c1oc([H])c(C([H])([H])C(=O)[O-])c1-c1c([H])c([H])c([H])c(C(=O)N([H])[H])c1[H] standalone.application.StandaloneApplication: {0} conditions are enabled standalone.application.TitlePanel: {0} TitlePanel new session standalone.application.ScorePanel: {0} ScorePanel new session standalone.application.ViewOptionsPanelButton: {0} ViewOptionsPanelButton new session standalone.application.HelpPanelButton: {0} HelpPanelButton new session standalone.application.ActionOptionsPanelButton: {0} ActionOptionsPanelButton new session standalone.application.UndoPanelButton: {0} UndoPanelButton new session standalone.application.CookbookPanelButton: {0} CookbookPanelButton new session standalone.application.HamburgerPanelButton: {0} HamburgerPanelButton new session interactive.application.appposeview.ElectronDensityGeom: {0} clear density... game.application.server.PrereleaseDialog: {0} PHASE PRE? : 0 game.application.server.PrereleaseDialog: {0} Normal game.application.server.PrereleaseDialog: {0} PreRelease game.application.server.CurlFetcher: {0} https://fold.it/api/get_solutions game.application.server.CurlFetcher: {0} https://fold.it/api/get_recipes game.application.GameApplication: {0} GROUP CHAT CHANNEL: GoScience game.application.server.CurlFetcher: {0} https://fold.it/api/get_puzzle_scores standalone.application.recipe.RecipeLibraryView: {0} RUNNING: 102831 standalone.application.MoveCountTracker: {0} Action not in MoveCountTracker map: RecipeRunnerAction standalone.application.MoveCountTracker: {0} Action not in MoveCountTracker map: RecipeRunnerAction standalone.application.MoveCountTracker: {0} Action not in MoveCountTracker map: RecipeRunnerAction standalone.application.MoveCountTracker: {0} Action not in MoveCountTracker map: RecipeRunnerAction ****** Encountered Crash at ../src/interactive/util/refcount/access_ptr.hh:217 ptr_.valid() 1 game_library.dylib 0x00000001145b6c54 game::application::CrashReporter::exit_callback(std::__1::basic_string, std::__1::allocator > const&, int, std::__1::basic_string, std::__1::allocator > const&) + 46 2 game_library.dylib 0x00000001145bacc8 void interactive::util::detail::checked_fxn_wrapper, std::__1::allocator > const&, int, std::__1::basic_string, std::__1::allocator > const&)>::operator(), std::__1::allocator > const&, int, std::__1::basic_string, std::__1::allocator > const&, void (game::application::CrashReporter::*)(std::__1::basic_string, std::__1::allocator > const&, int, std::__1::basic_string, std::__1::allocator > const&), 0>(interactive::util::access_ptr, std::__1::basic_string, std::__1::allocator > const&, int&&, std::__1::basic_string, std::__1::allocator > const&) + 164 3 game_library.dylib 0x00000001145babd7 void boost::_bi::list4 >, boost::arg<1>, boost::arg<2>, boost::arg<3> >::operator(), std::__1::allocator > const&, int, std::__1::basic_string, std::__1::allocator > const&)>, boost::_bi::rrlist3, std::__1::allocator > const&, int, std::__1::basic_string, std::__1::allocator > const&> >(boost::_bi::type, interactive::util::detail::checked_fxn_wrapper, std::__1::allocator > const&, int, std::__1::basic_string, std::__1::allocator > const&)>&, boost::_bi::rrlist3, std::__1::allocator > const&, int, std::__1::basic_string, std::__1::allocator > const&>&, int) + 71 4 game_library.dylib 0x00000001145baaf7 boost::detail::function::void_function_obj_invoker3, std::__1::allocator > const&, int, std::__1::basic_string, std::__1::allocator > const&)>, boost::_bi::list4 >, boost::arg<1>, boost::arg<2>, boost::arg<3> > >, void, std::__1::basic_string, std::__1::allocator > const&, int, std::__1::basic_string, std::__1::allocator > const&>::invoke(boost::detail::function::function_buffer&, std::__1::basic_string, std::__1::allocator > const&, int, std::__1::basic_string, std::__1::allocator > const&) + 47 5 game_library.dylib 0x0000000110c3bbe5 utility::exit_handler(char const*, int, std::__1::basic_string, std::__1::allocator > const&) + 110 6 game_library.dylib 0x0000000110c3c0f5 utility::exit(char const*, int, std::__1::basic_string, std::__1::allocator > const&, int) + 25 7 game_library.dylib 0x0000000114444029 interactive::util::access_ptr::indirection_shim::indirection_shim(interactive::util::access_ptr const&) + 201 8 game_library.dylib 0x00000001144a2db5 standalone::application::luaV2_creditbest_GetScore(lua_State*) + 81 9 game_library.dylib 0x000000010fd146e8 luaD_precall(lua_State*, lua_TValue*, int) + 1432 10 game_library.dylib 0x000000010fd22a3c luaV_execute(lua_State*, int) + 3372 11 game_library.dylib 0x000000010fd14b21 luaD_call(lua_State*, lua_TValue*, int) + 97 12 game_library.dylib 0x000000010fd14e44 luaD_pcall(lua_State*, void (*)(lua_State*, void*), void*, long, long) + 100 13 game_library.dylib 0x000000010fd0f322 lua_pcall(lua_State*, int, int, int) + 274 14 game_library.dylib 0x0000000114108144 interactive::application::shared::lua::LuaScripter::exec_string(std::__1::basic_string, std::__1::allocator > const&, std::__1::basic_string, std::__1::allocator >&) + 72 15 game_library.dylib 0x0000000114103d32 interactive::application::shared::lua::LuaExec::on_exec(std::__1::basic_string, std::__1::allocator > const&) + 46 16 game_library.dylib 0x000000011410603b void interactive::util::detail::checked_fxn_wrapper, std::__1::allocator > const&)>::operator(), std::__1::allocator >&, void (interactive::application::shared::lua::LuaExec::*)(std::__1::basic_string, std::__1::allocator > const&), 0>(interactive::util::access_ptr, std::__1::basic_string, std::__1::allocator >&) + 143 17 game_library.dylib 0x0000000114105f60 void boost::_bi::list2 >, boost::_bi::value, std::__1::allocator > > >::operator(), std::__1::allocator > const&)>, boost::_bi::list0>(boost::_bi::type, interactive::util::detail::checked_fxn_wrapper, std::__1::allocator > const&)>&, boost::_bi::list0&, int) + 64 18 game_library.dylib 0x0000000114105d00 boost::detail::function::void_function_obj_invoker0, std::__1::allocator > const&)>, boost::_bi::list2 >, boost::_bi::value, std::__1::allocator > > > >, void>::invoke(boost::detail::function::function_buffer&) + 26 19 game_library.dylib 0x0000000114321ec7 interactive::util::Thread::thread_entry_func() + 39 20 game_library.dylib 0x0000000114321a0c interactive::util::Thread::pthread_startup_helper(void*) + 30 21 libsystem_pthread.dylib 0x00007fff2076e8fc _pthread_start + 224 22 libsystem_pthread.dylib 0x00007fff2076a443 thread_start + 15 ERROR: ptr_.valid() ERROR:: Exit from: ../src/interactive/util/refcount/access_ptr.hh line: 217 ERROR: lua_errmsg ERROR:: Exit from: /Users/koepnick/rosetta_local/interactive/source/src/interactive/application/shared/lua/LuaScripter.cc line: 76