bkoep Staff Lv 1
After the first three rounds of our Coronavirus Binder Design challenge, we've selected 99 of the most promising Foldit player solutions for experimental testing!
Once a Foldit puzzle closes, we run some further analysis to figure out which designs are the most likely to fold and bind to the target. You can read more about some of that analysis on our previous blog post. To select promising designs, we consider Foldit score in addition to metrics that correlate with proper folding and others that correlate with binding.
We've combined those metrics to choose 33 designs from each of rounds one, two, and three of the Coronavirus Binder Design challenge. In total, 99 Foldit binder designs will be tested at the UW Institute for Protein Design, with the same experiments that have already begun for computationally-designed binders.
It will be a few more weeks before genes arrive and we can begin experiments on the Foldit designs. In the meantime, we'll continue to work on designing better binders in Foldit, so stay tuned for more puzzles! Be sure to review our tips for designing successful binders and watch coronavirus expert Lexi Walls, Ph.D. discuss early Foldit designs!
Below are the 99 designed proteins that we'll test for binding to the SARS-CoV-2 spike protein (click to view the full-size image). Remember to fill out our username sharing form if you want to see your username in Foldit updates!
2008926_c0022 johnmitch 2008926_c0023 johnmitch 2008926_c0026 PLAYER_7 2008926_c0034 PLAYER_4 2008926_c0036 ZeroLeak7 2008926_c0037 NinjaGreg 2008926_c0040 Galaxie 2008926_c0042 bertro 2008926_c0052 Galaxie 2008926_c0056 PLAYER_9 2008926_c0059 stomjoh 2008926_c0063 PLAYER_1 2008926_c0066 PLAYER_4 2008926_c0069 Galaxie, robgee, alwen 2008926_c0071 silent gene 2008926_c0079 Galaxie 2008926_c0108 mirp 2008926_c0113 LociOiling 2008926_c0141 PLAYER_6 2008926_c0142 dcrwheeler 2008926_c0175 spvincent 2008926_c0193 silent gene 2008926_c0197 PLAYER_10 2008926_c0200 PLAYER_4 2008926_c0252 christioanchauvin 2008926_c0253 Waya 2008926_c0352 actiasluna 2008926_c0382 PLAYER_4 2008926_c0425 PLAYER_4 2008926_c0429 stomjoh 2008926_c0450 stomjoh 2008926_c0474 robgee 2008926_y3560 PLAYER_14 2008984_c0001 actiasluna 2008984_c0002 Caraline_nelson, Phyx, mirp, PLAYER_17, jeff101, silent gene 2008984_c0003 Bletchley Park, spvincent 2008984_c0007 johnmitch 2008984_c0017 Migi 2008984_c0019 Waya 2008984_c0023 stomjoh 2008984_c0030 Phyx 2008984_c0034 Aubade01 2008984_c0036 silent gene, edpalas 2008984_c0043 ZeroLeak7 2008984_c0044 PLAYER_19 2008984_c0046 Steven Pletsch, PLAYER_18 2008984_c0058 PLAYER_12, frood66 2008984_c0087 Skippysk8s 2008984_c0089 actiasluna 2008984_c0103 mirp 2008984_c0129 MurloW
2008984_c0140 robgee 2008984_c0147 spmm 2008984_c0167 PLAYER_13 2008984_c0182 ZeroLeak7 2008984_c0205 NinjaGreg 2008984_c0239 PLAYER_15, frood66 2008984_c0250 PLAYER_9 2008984_c0313 spvincent 2008984_c0580 robgee 2008984_c0626 PLAYER_19 2008984_y5208 spvincent 2008984_y5300 spvincent 2008984_y7170 mirp 2008984_y9747 silent gene 2008984_y9800 silent gene 2009030_c0002 Bletchley Park, PLAYER_5, georg137, spvincent 2009030_c0005 Bletchley Park 2009030_c0008 ZeroLeak7 2009030_c0009 Steven Pletsch, PLAYER_18 2009030_c0015 Tehnologik1 2009030_c0017 actiasluna 2009030_c0020 Galaxie, jamiexq 2009030_c0021 PLAYER_16 2009030_c0027 dcrwheeler 2009030_c0030 Susume 2009030_c0031 crpainter 2009030_c0040 PLAYER_3 2009030_c0049 actiasluna, Jpilkington, ManVsYard 2009030_c0073 Crossed Sticks 2009030_c0083 alcor29 2009030_c0085 Waya 2009030_c0102 retiredmichael 2009030_c0105 Steven Pletsch 2009030_c0115 PLAYER_13 2009030_c0116 PLAYER_20 2009030_c0147 PLAYER_21 2009030_c0226 actiasluna 2009030_c0242 PLAYER_2 2009030_c0271 NinjaGreg 2009030_c0314 zeroblue 2009030_c0346 PLAYER_19 2009030_c0554 PLAYER_22 2009030_y0378 silent gene 2009030_y0533 PLAYER_21 2009030_y0703 fiendish_ghoul 2009030_y3873 PLAYER_10, PLAYER_17, Bruno Kestemont 2009030_y5708 Bruno Kestemont 2009030_y6236 Keresto