I invert the camera zoom and switch the right/middle mouse for Camera, and I'm having to re-set those each time I fire up a new client.
General Options > Controls > check 2nd and 3rd boxes.
I tried setting them, then immediately closing the client and reopening it, but they were still gone.
It's not just this setting that is lost when a client is closed: see my comments to feedback items by alcor29 and by georg137.
It's also not just on Mac: I'm on Windows, DevPrev (20211217-25ed22335d-win_x86-devprev), but I think the previous release had the same problem.
This is related to my post Display customizations never stick.