Devprev only.
I always work in selection mode.
In the new devprev I have experienced that clicking sometimes does nothing. This happens while creating bands, selecting segments. The only way to get it working again is clicking on the background, moving the protein a bit. Or wait some time.
Or try closing the Recipe Output window - I think it is eating the mouse events from a significant portion of the screen. In the screen locations where mouse events appear to do nothing, drag the mouse a little and see if the recipe output window scrolls.
http://fold.it/portal/node/2005050
I am having the same problem Timo, recipe output window scrolling and being apparently "trapped" in it.
See also https://fold.it/portal/node/2005050
The 20180426-5042fb62a9-win_x86-devprev release seems to have fixed this issue.
Closing this one, issue seems to have been resolved.