Brian the Prion Lv 1
In the Wikipedia article on protein folding, I read:
The process of folding often begins co-translationally, so that the N-terminus of the protein begins to fold while the C-terminal portion of the protein is still being synthesized by the ribosome.
I understand that this means that a protein will start curling up from one end, like a retractable tape measure, starting at one end. I imagine that one strategy for playing foldit would be to start at the N-terminus of the protein, find which parts of the developing protein are attracted to each other, and create a first-pass shape for the new chain. A second pass could then be used to compact the first-pass shape into a glob, and then the Wiggle tools could be used to find the lowest energy position associated with the compacted shape.
Is this a technique that successful folders are using?
Is there a place where the highest-scoring hand-folders share their techniques?
