More time for design Puzzles ?

Started by Bruno Kestemont

jeff101 Lv 1

http://foldit.wikia.com/wiki/Distance_Maps and http://memorize.com/distance-and-contact-maps show Distance and Contact Maps along-side their respective 3D images for many different proteins. Images are classified as in the SCOPe database (http://scop.berkeley.edu), and http://memorize.com/distance-and-contact-maps can shuffle the images in multiple-choice and matching modes to help you learn the patterns in them.

Skippysk8s - Are these the "Rama Map" links you mentioned above?

inkycatz Lv 1

It's an interesting observation you've made here. I've boosted this thread to the team in hopes they'll have some time to share some thoughts (if not directly in-thread, than via email which I can sum).

Bruno Kestemont Lv 1

Just curious how much total "hand fold" time the other players need for several types of puzzles (the total time you need in front of your computer for pure hand interventions and checking of short lasting tools and recipes - not included the time to check and change long lasting recipes).

I would say for myself that I basically "hand fold" only the first hours within the 3 first days, the 4 latest days being mostly covered by long lasting recipes.

Here is my estimated mean HF time per puzzle solution: (I may try several solutions):

1) Revisiting puzzles without bridge: 10 min
2) Revisiting puzzles with expected bridges: 20 min
3) Refining, second round etc: 30 min
4) Peptides, hot spots etc (small designs): 45 min
5) Free design: 1h
6) Symmetric: 1h30
7) Design, ideal loops ("no rebuild"): 8h
8) De Novo free style: 2h
9) Contact: 8h
10) Electron Density refining, already in the cloud: 1h
11) Electron Density refining, not yet in the cloud: 5h
12) Electron Density, short and easy, de novo: 10h
13) Electron Density, long and complex, de novo: 20h