Robust folding of a de novo designed ideal protein even with most of the core mutated to valine

Started by Vincera

LociOiling Lv 1

As long as we're on the K&K track, there's also Consistency principle for protein design, which might be of interest.

Or there's the aardvark design principle, which is "change everything to aardvark, aardvark, aardvark, make helices, and hope for the best". (Still haven't gotten a complete aardvark yet, however.)