alcor29 Lv 1
Is there anything to report on a possible current effort or progress being made in rebalancing or refining the accuracy of foldit scoring internally as opposed to externally by using filters?
Fall Science Chat!
Started by smortier
Bruno Kestemont Lv 1
I've read that the Foldit optimizer has some bias in favour of helices. Is this bias random? If not, why can't you correct it with some filter penalty?
Bruno Kestemont Lv 1
For membrane proteins, orange should be outside. Do you correct the scoring function for these "lipidic" (or partially lipidic) puzzles?
Bruno Kestemont Lv 1
Now we can design drugs. Once you have a drug design, how can you produce this exact drug in the labo?
alcor29 Lv 1
Aflatoxin 1445
The reverse (grayed/frozen) side of the aflatoxin grabber seems to have the structure of an ideal funnel trap to let the aflatoxin enter or even be 'sucked' in. If that's true and the funnel side-chains don't clog the passage, what we need to do is to block the rear entrance and 'grab' the aflatoxin in the 'pocket' like a baseball in a glove to keep if from getting through or backing out. What do you think?
