New Release!

Started by jflat06

jflat06 Staff Lv 1

Hey everyone!

We're releasing the New Chapter of Foldit today! This release brings Foldit more in line with the state-of-the-art of Rosetta's scoring. This new score function has become the Baker Lab's new standard. It is a bit slower, but provides better accuracy, so when you get a high score in Foldit, there's a better chance you've gotten a high score in real life!

Alongside the scoring changes, we've made some other changes that you can view below.

  • Wiggle
  • Iterations have been modified to represent a machine-independent 'work' unit.

  • Behavior
  • Wiggle Power added - Wiggle Power allows you to balance speed and points. In particular, low Wiggle Power wont try to idealize the protein as it runs, while medium will try the basics, and high will try to optimize everything.

  • Scoring
  • Scoring has received a major overhaul to be more scientifically accurate. Please see the related blog post for more details.
  • Added an 'Idealization' score part.

  • Lua
  • Added undo.SetUndo(boolean) that enables or disables pushes onto the undo stack.

  • Bug Fixes
  • Rebuild should now pay attention to cutpoint bands unless you have them disabled.
  • Bands between symmetric copies of the protein should now be applied correctly.

A particularly big thanks to all of the players who gave feedback and helped debug the newchapter in the several weeks that it was available for testing! We know there are some remaining issues, and we'll continue to work on these in the coming days.

We're still very interested in your feedback, and would appreciate any that you can give us regarding this update. Thanks!

spvincent Lv 1

Rebuild still appears to be culling low-scoring structures internally. For reasons explained in feedback previously, this is undesirable behaviour.

wisky Lv 1

From what I had learned in Organic Chemistry, old wiggle seemed very stiff compared to the motion of the hyper-fluid small molecules that we worked with. I didn't want to mention it since it seemed like a pretty good approximation. It just didn't quite capture the nature of "buckling" as I had pictured it…

However…

New wiggle… at high power…

<3 <3 <3 <3 <3 <3 <3 <3 <3 <3 <3 <3 <3 <3 <3 <3 <3 <3 <3 <3 <3 <3 <3 <3 <3 <3 <3 (yes those are hearts!)

Also, from what I've gathered, rebuild code hasn't actually changed, just wiggle. Rebuild still works exactly the same (given the same exact set of inputs) from what I can tell.

Susume Lv 1

Rebuild is definitely not the same; see the data in feedback. Poses with sidechain clashes that could be resolved by shake are being excluded, other low scoring poses are being excluded, and net gains available from rebuilds are down.