The Date: 17 September 2015 (Thursday) Add your questions to this post!</a> No questions yet? Bookmark this post and add them closer to the event.
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It seems that many of the 'revisit' puzzles lately have disulfides and filter point bonuses for disulfides. Could we discuss in general how we are doing with these revisiting puzzles? Are the scientists generally pleased that the game is progressing, and how well do the revisiting puzzles support this? Qualitatively, or quantitatively.
I am particularly curious if the top scoring puzzles with disulfides show much diversity. Or do the top 10 or 20 scores all converge on the same disulfide ensemble? Has there been any case recently where a non-native ensemble of disulfides has scored very well?
Thanks.
Foldit attracted me when players found a structure "that scientists were looking for years before".
Does it happen again? Can we say that the new Foldit strategy (what is it exactly?) pays: de nov with structure prediciton, then contact or electron density, then what happens? then do you find new native structures ?
\database\rotamer\ExtendedOpt1-5
It is necessary to remove the frequent requests to the hard disk as it wears out its mechanical parts.
These functions must be in RAM. access the hard disk should be minimal
thanks
I wonder why there is a 3D structure in the revisit puzzles. Has this any meaning? Is it a known native that you just crashed a little bit in order to let us "recovering" it?
Or is it some probable structure?
Why not a kind of starting flat de novo each time?
I experienced that starting from the given structure and compacting it gives me better result than hand working from scratch "Ideal" helices and sheets like for a de nove puzzle.
So I don't know: is it my hand technique that is worst than simply starting from what states, or has the given structure some meaning?
On the revisit puzzles, sometimes I have made them into an extended beta strand first. When I have done this, I usually scored better starting from the 3D structure given than from an extended beta strand. I have also noticed that for revisit puzzles with disulfides, I often scored better when I used a different combination of disulfides than what the starting 3D structure was near.
Where do the starting 3D structures for the revisit puzzles come from? Are they predictions from some server? Are they scrambled native structures? Are they the same starting 3D structures used in the original puzzles?
Thanks!
In the current client, loaded and saved quicksaves are cached inside the client. Please change the file handling so that upon reloading a quicksave the client checks the file timestamp on disk against the cached version, in case of a changed file date or time the client should close (not flush !) and reopen and re-read the file from disk in share mode. I am happy to explain why this is useful in a PM with the devs.
