Placeholder image of a protein
Icon representing a puzzle

1003: Revisiting Puzzle 141: Rosetta Decoy 5

Closed since over 11 years ago

Intermediate Overall Prediction

Summary

Created
October 21, 2014
Expires
Max points
100
Description

This is a throwback puzzle to the early days of Foldit. This protein helps to regulate oxidation in the cell; the starting structure is a model produced by Rosetta. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

Top groups

  1. Avatar for Italiani Al Lavoro 11. Italiani Al Lavoro 13 pts. 9,615
  2. Avatar for Deleted group 12. Deleted group pts. 9,557
  3. Avatar for Russian team 13. Russian team 7 pts. 9,549
  4. Avatar for Deleted group 14. Deleted group pts. 9,364
  5. Avatar for xkcd 15. xkcd 4 pts. 9,346
  6. Avatar for It's over 9000! 16. It's over 9000! 3 pts. 9,315
  7. Avatar for Natural Abilities 17. Natural Abilities 2 pts. 9,085
  8. Avatar for Deleted group 18. Deleted group pts. 9,075
  9. Avatar for Waverki 19. Waverki 1 pt. 8,750
  10. Avatar for Eὕρηκα! Heureka! 20. Eὕρηκα! Heureka! 1 pt. 8,711
  1. Avatar for Altercomp 181. Altercomp Lv 1 1 pt. 8,679
  2. Avatar for Sci1217 182. Sci1217 Lv 1 1 pt. 8,678
  3. Avatar for Lumir 183. Lumir Lv 1 1 pt. 8,675
  4. Avatar for SzalonyMajster 184. SzalonyMajster Lv 1 1 pt. 8,675
  5. Avatar for lzhchild 185. lzhchild Lv 1 1 pt. 8,666
  6. Avatar for JUMELLE54 186. JUMELLE54 Lv 1 1 pt. 8,661
  7. Avatar for Tac1 187. Tac1 Lv 1 1 pt. 8,659
  8. Avatar for jstoddard 188. jstoddard Lv 1 1 pt. 8,652
  9. Avatar for luedtkenick 189. luedtkenick Lv 1 1 pt. 8,647
  10. Avatar for Cerzax 190. Cerzax Lv 1 1 pt. 8,645

Comments

bkoep Staff Lv 1

Not necessarily. In general, cysteines that are far apart in sequence can contribute more to the stability of a protein fold.

Since these two cysteines are so close in sequence, we can assume that this disulfide bond contributes very little to the stability of the protein. This makes sense, if we consider that this protein is involved in regulating the reduction potential of the cell: In order for the protein to function, the disulfide should be readily oxidized (formed) or reduced (broken) in response to changing conditions in the cell. This particular protein must remain folded even when the disulfide bond is reduced, so that the two cysteines are properly positioned and ready to bond.

brow42 Lv 1

I see! So, this is a redox potential buffer, analogous to a pH buffer! Thank you for the response!