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1012: Unsolved De-novo Freestyle

Closed since over 11 years ago

Intermediate Overall Prediction

Summary

Created
November 12, 2014
Expires
Max points
100
Description

We are giving you this unsolved vascular endothelial growth factor protein as a freestyle puzzle to start. We will post another round for this protein later, giving you server predictions as starting models, but we'd like you to just work with this extended chain for now (as homology-based methods have failed to solve this protein). More info in the puzzle comments, including a blogpost about this unsolved protein.

Top groups

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  6. Avatar for University of Washington 26. University of Washington 1 pt. 5,603
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    1. Galaxie Lv 1
    100 pts. 9,072
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  3. Avatar for gmn 3. gmn Lv 1 80 pts. 9,054
  4. Avatar for jamiexq 4. jamiexq Lv 1 71 pts. 9,050
  5. Avatar for alwen 5. alwen Lv 1 63 pts. 9,044
  6. Avatar for Vredeman 6. Vredeman Lv 1 55 pts. 9,043
  7. Avatar for Lindata 7. Lindata Lv 1 49 pts. 9,037
  8. Avatar for reefyrob 8. reefyrob Lv 1 43 pts. 9,031
  9. Avatar for LociOiling 9. LociOiling Lv 1 37 pts. 9,030
  10. Avatar for brgreening 10. brgreening Lv 1 32 pts. 9,024

Comments

beta_helix Staff Lv 1

The secondary structure predictions for this puzzle haven't come back from the SAM server yet, so these are the ones that were used for the starting chain:

The higher the number, the higher the confidence of the secondary structure prediction above it.

In this puzzle, the "High Wiggle Power" option has been disabled.

Please read the new blogpost about this protein.

beta_helix Staff Lv 1

The sequence logo predicted by the SAM server finally finished:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.