Placeholder image of a protein
Icon representing a puzzle

1012: Unsolved De-novo Freestyle

Closed since over 11 years ago

Intermediate Overall Prediction

Summary

Created
November 12, 2014
Expires
Max points
100
Description

We are giving you this unsolved vascular endothelial growth factor protein as a freestyle puzzle to start. We will post another round for this protein later, giving you server predictions as starting models, but we'd like you to just work with this extended chain for now (as homology-based methods have failed to solve this protein). More info in the puzzle comments, including a blogpost about this unsolved protein.

Top groups

  1. Avatar for xkcd 21. xkcd 1 pt. 7,714
  2. Avatar for Mojo Risin' 22. Mojo Risin' 1 pt. 7,536
  3. Avatar for It's over 9000! 23. It's over 9000! 1 pt. 7,311
  4. Avatar for freefolder 24. freefolder 1 pt. 7,076
  5. Avatar for Czech National Team 25. Czech National Team 1 pt. 6,600
  6. Avatar for University of Washington 26. University of Washington 1 pt. 5,603
  7. Avatar for foldeRNA 27. foldeRNA 1 pt. 5,465
  8. Avatar for Eὕρηκα! Heureka! 28. Eὕρηκα! Heureka! 1 pt. 5,260
  9. Avatar for DSN @ Home 29. DSN @ Home 1 pt. 5,192
  10. Avatar for Crunching Family 30. Crunching Family 1 pt. 5,106
  1. Avatar for Merf 81. Merf Lv 1 15 pts. 8,052
  2. Avatar for SKSbell 82. SKSbell Lv 1 15 pts. 8,042
  3. Avatar for vuvuvu 83. vuvuvu Lv 1 14 pts. 8,034
  4. Avatar for Bushman 84. Bushman Lv 1 14 pts. 8,032
  5. Avatar for Anfinsen_slept_here 85. Anfinsen_slept_here Lv 1 14 pts. 8,024
  6. Avatar for TomTaylor 86. TomTaylor Lv 1 13 pts. 8,013
  7. Avatar for Jim Fraser 87. Jim Fraser Lv 1 13 pts. 7,996
  8. Avatar for bamh 88. bamh Lv 1 13 pts. 7,978
  9. Avatar for jstoddard 89. jstoddard Lv 1 12 pts. 7,975
  10. Avatar for cobaltteal 90. cobaltteal Lv 1 12 pts. 7,970

Comments

beta_helix Staff Lv 1

The secondary structure predictions for this puzzle haven't come back from the SAM server yet, so these are the ones that were used for the starting chain:

The higher the number, the higher the confidence of the secondary structure prediction above it.

In this puzzle, the "High Wiggle Power" option has been disabled.

Please read the new blogpost about this protein.

beta_helix Staff Lv 1

The sequence logo predicted by the SAM server finally finished:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.