Placeholder image of a protein
Icon representing a puzzle

1012: Unsolved De-novo Freestyle

Closed since over 11 years ago

Intermediate Overall Prediction

Summary

Created
November 12, 2014
Expires
Max points
100
Description

We are giving you this unsolved vascular endothelial growth factor protein as a freestyle puzzle to start. We will post another round for this protein later, giving you server predictions as starting models, but we'd like you to just work with this extended chain for now (as homology-based methods have failed to solve this protein). More info in the puzzle comments, including a blogpost about this unsolved protein.

Top groups

  1. Avatar for Anthropic Dreams
    1. Anthropic Dreams
    100 pts. 9,072
  2. Avatar for Beta Folders 2. Beta Folders 84 pts. 9,033
  3. Avatar for Void Crushers 3. Void Crushers 70 pts. 8,990
  4. Avatar for L'Alliance Francophone 4. L'Alliance Francophone 58 pts. 8,903
  5. Avatar for Go Science 5. Go Science 48 pts. 8,826
  6. Avatar for Gargleblasters 6. Gargleblasters 39 pts. 8,782
  7. Avatar for Contenders 7. Contenders 32 pts. 8,760
  8. Avatar for Deleted group 8. Deleted group pts. 8,657
  9. Avatar for FoldIt@Netherlands 9. FoldIt@Netherlands 20 pts. 8,655
  10. Avatar for HMT heritage 10. HMT heritage 16 pts. 8,546
  1. Avatar for Bletchley Park 31. Bletchley Park Lv 1 1 pt. 8,744
  2. Avatar for ManVsYard 32. ManVsYard Lv 1 1 pt. 8,741
  3. Avatar for gitwut 33. gitwut Lv 1 1 pt. 8,738
  4. Avatar for mimi 34. mimi Lv 1 1 pt. 8,732
  5. Avatar for Bruno Kestemont 35. Bruno Kestemont Lv 1 1 pt. 8,731
  6. Avatar for silverberg 36. silverberg Lv 1 1 pt. 8,725
  7. Avatar for Ashrai 37. Ashrai Lv 1 1 pt. 8,670
  8. Avatar for puxatudo 38. puxatudo Lv 1 1 pt. 8,668
  9. Avatar for BootsMcGraw 39. BootsMcGraw Lv 1 1 pt. 8,617
  10. Avatar for spvincent 40. spvincent Lv 1 1 pt. 8,602

Comments

beta_helix Staff Lv 1

The secondary structure predictions for this puzzle haven't come back from the SAM server yet, so these are the ones that were used for the starting chain:

The higher the number, the higher the confidence of the secondary structure prediction above it.

In this puzzle, the "High Wiggle Power" option has been disabled.

Please read the new blogpost about this protein.

beta_helix Staff Lv 1

The sequence logo predicted by the SAM server finally finished:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.