1012: Unsolved De-novo Freestyle

Closed since over 11 years ago

Summary

• Created: November 12, 2014
• Expires: November 20, 2014 at 05:00 UTC
• Max points: 100

Description

We are giving you this unsolved vascular endothelial growth factor protein as a freestyle puzzle to start. We will post another round for this protein later, giving you server predictions as starting models, but we'd like you to just work with this extended chain for now (as homology-based methods have failed to solve this protein). More info in the puzzle comments, including a blogpost about this unsolved protein.

Top groups

• 1. Anthropic Dreams 100 pts. 9,072
• 2. Beta Folders 84 pts. 9,033
• 3. Void Crushers 70 pts. 8,990
• 4. L'Alliance Francophone 58 pts. 8,903
• 5. Go Science 48 pts. 8,826
• 6. Gargleblasters 39 pts. 8,782
• 7. Contenders 32 pts. 8,760
• 8. Deleted group pts. 8,657
• 9. FoldIt@Netherlands 20 pts. 8,655
• 10. HMT heritage 16 pts. 8,546

Top soloists

• 11. Already taken 82 pts. 8,837
• 12. Bruno Kestemont 80 pts. 8,824
• 13. Timo van der Laan 79 pts. 8,817
• 14. viosca 77 pts. 8,796
• 15. g_b 76 pts. 8,790
• 16. mirp 74 pts. 8,782
• 17. Vredeman 73 pts. 8,773
• 18. Threeoak 71 pts. 8,769
• 19. goastano 70 pts. 8,769
• 20. Orcus 68 pts. 8,766

Comments

[beta_helix]

The secondary structure predictions for this puzzle haven't come back from the SAM server yet, so these are the ones that were used for the starting chain:

The higher the number, the higher the confidence of the secondary structure prediction above it.

In this puzzle, the "High Wiggle Power" option has been disabled.

Please read the new blogpost about this protein.

[beta_helix]

The sequence logo predicted by the SAM server finally finished:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.