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1027: 80 Residue Symmetric Tetramer Design

Closed since about 11 years ago

Intermediate

Summary

Created
December 18, 2014
Expires
Max points
100
Description

NOTE: This puzzle has been closed and reposted as Puzzle 1027b.


This puzzle again uses separate "Core Existence" filters for the monomer unit and the symmetric complex. Click the "Show" checkbox beneath the Core Existence filter to see which residues have been identified as Core (orange), Boundary (green), or Surface (blue). There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!




This puzzle will be online for two and half weeks, so take the opportunity to try several different designs!

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Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Monomer: Ensures that at least 30% of the residues are buried in the core of the monomer unit.

Core Existence: Complex: Ensures that at least 38% of the residues are buried in the core of the entire complex (including the interface between monomer units).

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure Design: Penalizes GLY, ALA, and PRO residues in helices and sheets.

bkoep Staff Lv 1

Unfortunately, Foldit cannot handle the insertion and deletion of residues in symmetric puzzles. This is a feature we'd like to add, but it will require a (surprisingly) substantial amount of work.

bkoep Staff Lv 1

This looks like a bug, but I think we can avert it by reposting the puzzle.

Thanks for bringing this to our attention, Timo!

retiredmichael Lv 1

could you check the boundary condition between too many and too few in the complex, seems maybe a bit too sensitive. keep jumping from - 200 too few and - 400 too many

played with it for a bit and could not find a place between these 2 readings