Placeholder image of a protein
Icon representing a puzzle

1028: Revisiting Electron Density Puzzle 730

Closed since about 11 years ago

Intermediate Overall Prediction Electron Density

Summary

Created
December 20, 2014
Expires
Max points
100
Description

We're revisiting this old electron density puzzle to test some recent changes to Foldit! In this puzzle, there are bits of density which don't belong to the copy of the protein that you're working on. You'll have to decide which bits of density to match with, and which bits to ignore. Try to fit the protein into the density to get the best score! Secondary structure predictions are posted in the puzzle comments along with info about available tools in the game.

Top groups

  1. Avatar for FoldIt@Netherlands 11. FoldIt@Netherlands 10 pts. 10,648
  2. Avatar for Russian team 12. Russian team 8 pts. 10,608
  3. Avatar for HMT heritage 13. HMT heritage 6 pts. 10,470
  4. Avatar for Deleted group 14. Deleted group pts. 10,370
  5. Avatar for Italiani Al Lavoro 15. Italiani Al Lavoro 3 pts. 10,219
  6. Avatar for Herobrine's Army 16. Herobrine's Army 2 pts. 10,000
  7. Avatar for Repro-men 17. Repro-men 2 pts. 9,650
  8. Avatar for freefolder 18. freefolder 1 pt. 8,946
  9. Avatar for Crunching Family 19. Crunching Family 1 pt. 7,900
  10. Avatar for Geekdo 20. Geekdo 1 pt. 7,687
  1. Avatar for pauldunn 11. pauldunn Lv 1 81 pts. 11,402
  2. Avatar for nicobul 12. nicobul Lv 1 79 pts. 11,365
  3. Avatar for Deleted player 13. Deleted player pts. 11,330
  4. Avatar for bertro 14. bertro Lv 1 76 pts. 11,325
  5. Avatar for Threeoak 15. Threeoak Lv 1 74 pts. 11,227
  6. Avatar for Bruno Kestemont 16. Bruno Kestemont Lv 1 72 pts. 11,169
  7. Avatar for viosca 17. viosca Lv 1 71 pts. 11,160
  8. Avatar for nemo7731 18. nemo7731 Lv 1 69 pts. 11,160
  9. Avatar for Vredeman 19. Vredeman Lv 1 68 pts. 11,060
  10. Avatar for gloverd 20. gloverd Lv 1 66 pts. 11,032

Comments

bkoep Staff Lv 1

Here is the sequence logo predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

The above predictions are already on the starting model (based on the horizontal lines in the above figure).
______________

Cutaway view hint:
If you hover your mouse over a segment and type shift-Q, the game will hide parts of the protein and cloud that are not in the same plane as that segment - it cuts down on how much cloud you see at one time and makes it easier to focus. Q returns to normal view.

Timo van der Laan Lv 1

This is the third repeat of an ED puzzle. I would really like to see one that hasnt been solved yet.
BTW, these kind of puzzles are now very good playable, congrats to the devs on the speed improvement since NC.

bkoep Staff Lv 1

The difficulty is finding test cases appropriate for Foldit. Most unsolved cases involve low-resolution density maps for very large proteins.

We've been running these revisited puzzles to test new ED code and recalibrate density scoring, but we're also anxious for the next unsolved density map!