Placeholder image of a protein
Icon representing a puzzle

1142: Unsolved De-novo Freestyle 58

Closed since over 10 years ago

Intermediate Overall Prediction

Summary

Created
September 28, 2015
Expires
Max points
100
Description

The structure of this protein is still unknown. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!



Sequence:


EDVLSSDIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGR

Top groups

  1. Avatar for BOINC@Poland 11. BOINC@Poland 11 pts. 8,975
  2. Avatar for xkcd 12. xkcd 9 pts. 8,684
  3. Avatar for Italiani Al Lavoro 13. Italiani Al Lavoro 7 pts. 8,502
  4. Avatar for Androids 14. Androids 5 pts. 8,497
  5. Avatar for Penn State Biomolecular Engineers 15. Penn State Biomolecular Engineers 4 pts. 8,165
  6. Avatar for It's over 9000! 16. It's over 9000! 3 pts. 7,714
  7. Avatar for Deleted group 17. Deleted group pts. 7,129
  8. Avatar for freefolder 18. freefolder 1 pt. 6,996
  9. Avatar for Natural Abilities 19. Natural Abilities 1 pt. 6,540
  10. Avatar for DSN @ Home 20. DSN @ Home 1 pt. 2,414
  1. Avatar for Cyberkashi 191. Cyberkashi Lv 1 1 pt. 5,892
  2. Avatar for jpstephen94 192. jpstephen94 Lv 1 1 pt. 5,868
  3. Avatar for oclaim 193. oclaim Lv 1 1 pt. 5,769
  4. Avatar for Sticho12 194. Sticho12 Lv 1 1 pt. 5,736
  5. Avatar for nitrobacter 195. nitrobacter Lv 1 1 pt. 5,597
  6. Avatar for Mohambone 196. Mohambone Lv 1 1 pt. 5,572
  7. Avatar for vuvuvu 197. vuvuvu Lv 1 1 pt. 5,552
  8. Avatar for karost 198. karost Lv 1 1 pt. 5,456
  9. Avatar for Truncheon Luncheon 199. Truncheon Luncheon Lv 1 1 pt. 5,424
  10. Avatar for Sydefecks 200. Sydefecks Lv 1 1 pt. 5,294

Comments

Skippysk8s Lv 1

my scoreboard is totally different from what is showing up on my page and on the listings under this puzzle… others' scores also wrong
Is there a server problem with this puzzle?

Bautho Lv 1

Do you actually use a different score function for proteins that have a high content in hydrophobic amino acids like this protein?`

Since the sequence is predicted to have at least 4 or 5 transmembrane regions (see below, where the Ms show the membrane parts), do you distinguish between these hydrophobic parts and the soluble parts?

Or do you really want to solve the structure in solution (considering that this protein would not be stable in solution and rather form aggregates)?

##############################################################################
OCTOPUS result file
Generated from http://octopus.cbr.su.se/ at 2015-10-02 20:37:30
Total request time: 2.84 seconds.
##############################################################################

Sequence name: query_sequence
Sequence length: 176 aa.
Sequence:
EDVLSSDIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFL
DKELTGLNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARGMAILGPTFTLDALV
ECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGR

OCTOPUS predicted membrane topology:
oooooMMMMMMMMMMMMMMMMMMMMMiiiiiiiiiiMMMMMMMMMMMMMMMMMMMMMooo
ooooooMMMMMMMMMMMMMMMMMMMMMiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiii
MMMMMMMMMMMMMMMMMMMMMoMMMMMMMMMMMMMMMMMMMMMiiiiiiiiiiiii