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1221: Disordered Electron Density: Round 1

Closed since almost 10 years ago

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Summary

Created
April 17, 2016
Expires
Max points
100
Description

NOTE: Because many players have had trouble playing this puzzle, the puzzle has been made worth zero points, and it will not contribute to player rankings. However, this puzzle is still of unique scientific interest, and we encourage players to work on it if they are able!



This is a big one! This electron density puzzle features two proteins: the first is a large well-ordered helical protein that is mostly frozen in place. This binder protein has two flexible loops that bind a second, mostly disordered, substrate protein. The substrate protein is provided here as an extended chain, and is completely flexible. We know that the substrate protein is bound to the binder protein somewhere in this crystal structure. But it seems that the substrate is able to adopt several different shapes, making the electron density very difficult to interpret. We’re asking Foldit players to help us find the ways that the substrate protein can bind to the binder protein! Fold up the extended chain and dock it next to the flexible loops of the binder to improve your score!

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Comments

Susume Lv 1

I and some others are getting this message when trying to load 1221:
"A timeout was reached due to excessive server load. Sorry for the inconvenience, please try again later."

Win 7 devprev

gitwut Lv 1

The description for this puzzle is very poor. What is the deal with the scattered, partial hydrophobes seemingly unattached to any protein yet they have unique segment numbers? The ease with which it crashes makes it unworkable.

LociOiling Lv 1

By checking "disable network timeouts" on the login screen, I was able to get this puzzle open.

I'd love to hear the explanation of why that is, but good enough for now.

Not sure if there's a good reason to leave "disable network timeouts" unchecked. Having it unchecked did not prevent clients from hanging after the most recent server outage.

LociOiling Lv 1

Checking "disable network timeouts" on the login screen let it download without the timeout message.

Even with no scripts running, the 1221 client is using nearly twice the memory of a client with EDRW running on puzzle 1220. Check your memory usage on the performance tab of task manager, anything above 90% might be an issue.