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1261: Tuberculosis Challenge - Phase 2: Predicted Contacts

Closed since over 9 years ago

Intermediate Overall Prediction Predicted Contacts

Summary

Created
July 18, 2016
Expires
Max points
100
Description

NOTE: The expiration date for this puzzle has been extended by 1 week, due to the size and complexity of the problem.



This is a follow-up puzzle for Puzzle 1258, now with Predicted Contacts to help guide your folding! See the blog for information on using the contact map. You can see the predicted contacts for this protein by clicking the Contact Map button in the Main menu (Selection Interface) or in the Actions tab (Classic Interface). You will notice that different contacts are shown in different shades of green, with brighter green contacts indicating stronger predictions. Players will be able to load in manual saves from Puzzle 1258 and use them as a starting point here. This protein is currently being investigated for drug discovery against Tuberculosis (TB), although its structure is still unknown.



Sequence:


MLTFVARPYLIPSESMEPTLHGCSTCVGDRIMVDKLSYRFGSPQPGDVIVFRGPPSWNVGYKSIRSHNVAVRWVQNALSFIGFVPPDENDLVKRVIAVGGQTVQCRSDTGLTVNGRPLKEPYLDPATMMADPSIYPCLGSEFGPVTVPPGRVWVMGDNRTHSADSRAHCPLLCTDDPLPGTVPVANVIGKARLIVWPPSRWGVVRSVNPQQGR

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Comments

toshiue Lv 1

Closed my client for an hour, restarted, got an automatic update, and was reset to the beginning of the puzzle (1261). None of my saved solutions are listed.

toshiue Lv 1

As mentioned above, the continuation of 1258 and 1261, please consider letting us have such. Am just beginning to get a handle on contact maps, lost my entire puzzle 4 hours ago in a restart and update. Would like to see all this end on a positive note, and actually see if I've learned something going forward. Version 3, please.

Susume Lv 1

Some homologs, like the E. coli, have their catalytic lysine at a different location than the TB, and therefore must have a partially different shape. Is it possible to give more weight to contacts predicted from homologs with the similar active site residue locations, and less weight to contacts from homologs with active site residues located elsewhere?