1266: Disordered Electron Density: Crystal Symmetry

Closed since over 9 years ago

Summary

• Created: August 02, 2016
• Expires: August 08, 2016 at 23:00 UTC
• Max points: 100

Description

Note: This puzzle is worth zero points, and will not affect player rankings. Solutions from Puzzle 1230 or Puzzle 1221 cannot be loaded correctly into this puzzle; players should avoid loading previous solutions into this puzzle.



This is a followup to Puzzle 1230, now with crystal symmetry! Many of the solutions from Puzzle 1230 had severe clashes when modeled in the crystal lattice; this puzzle includes nearby symmetric copies in the crystal lattice. Because it is slow to display all symmetric proteins, we recommend that players hide the symmetric copies during most of their folding. You can hide symmetric copies in the View menu by unchecking the box "Show Symmetric Chains" (make sure you've already checked Menu->General Options->Show advanced GUI).



This electron density puzzle features two proteins: the first is a large well-ordered helical protein that is mostly frozen in place. This binder protein has two flexible loops that bind a second, mostly disordered, substrate protein. The substrate protein is provided here as an extended chain, and is completely flexible. We know that the substrate protein is bound to the binder protein somewhere in this crystal structure. But it seems that the substrate is able to adopt several different shapes, making the electron density very difficult to interpret. We’re asking Foldit players to help us find the ways that the substrate protein can bind to the binder protein! Fold up the extended chain and dock it next to the flexible loops of the binder to improve your score!

Top groups

• 1. Deleted group pts. 11,670
• 2. Anthropic Dreams 73 pts. 11,620
• 3. Gargleblasters 52 pts. 10,447
• 4. Go Science 36 pts. 9,954
• 5. Contenders 24 pts. 9,348
• 6. Void Crushers 16 pts. 8,782
• 7. Beta Folders 10 pts. 8,713
• 8. L'Alliance Francophone 6 pts. 7,885
• 9. Italiani Al Lavoro 4 pts. 7,118
• 10. It's over 9000! 2 pts. 5,826

Top soloists

• 1. Steven Pletsch 100 pts. 11,670
• 2. phi16 97 pts. 11,620
• 3. g_b 93 pts. 11,611
• 4. hpaege 90 pts. 10,790
• 5. poiuyqwert 86 pts. 10,677
• 6. tomespen 83 pts. 10,447
• 7. Glen B 80 pts. 10,422
• 8. dcrwheeler 77 pts. 10,242
• 9. caglar 74 pts. 9,954
• 10. Mark- 71 pts. 9,348

Comments

[Mike Lewis]

Indeed, it's like being stuck on a train stopped between stations in the middle of nowhere, all the passengers are waiting for an announcement from the guard.

[Merf]

Egad!!! Yeeeeehaa, even! We have scoring. Thank you it's nice to have it back.

Merf.

[jamiexq]

This is not just about a puzzle having problems and you don't have to play it if you don't want your client crashing every few minutes. After this puzzle crashes your client, you cannot even log back into foldit.
These issues keep adding up, I have to disable ALL sound devices on my windows 10 laptop to even ATTEMPT to play any puzzle, much less, playing this zero point puzzle and then not being able to get back in to play ANY puzzle.

[toshiue]

Along the lines of what gitwut initially posted, and to put a scale on what he reported, my first ten consecutive attempts to open the puzzle all locked the system as soon as the puzzle initially appeared on screen. Hardware-wise, something less than what gitmut is running. i7-4770@3.4GHz, Win7-64, 32GB ram, GTX645 w/ 2GB, and I can't even get it started. Would have loved to have played this, wish such had been possible.