Placeholder image of a protein
Icon representing a puzzle

1302: 70 Residue Monomer Design: No Rebuilding!

Closed since over 9 years ago

Intermediate

Summary

Created
October 27, 2016
Expires
Max points
100
Description

This puzzle is similar to recent design puzzles, but we'd like players to avoid using the Rebuild tool. We suspect that the Rebuild tool has been introducing some problematic backbones into Foldit player designs, so the Rebuild tool has been deactivated in this puzzle. In most cases, the Remix tool can be used as an alternative to Rebuild. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Contenders
    1. Contenders
    100 pts. 10,618
  2. Avatar for Beta Folders 2. Beta Folders 73 pts. 10,598
  3. Avatar for Anthropic Dreams 3. Anthropic Dreams 52 pts. 10,569
  4. Avatar for Go Science 4. Go Science 36 pts. 10,542
  5. Avatar for Void Crushers 5. Void Crushers 24 pts. 10,468
  6. Avatar for L'Alliance Francophone 6. L'Alliance Francophone 16 pts. 10,406
  7. Avatar for Gargleblasters 7. Gargleblasters 10 pts. 10,271
  8. Avatar for Deleted group 8. Deleted group pts. 9,741
  9. Avatar for Italiani Al Lavoro 9. Italiani Al Lavoro 4 pts. 9,242
  10. Avatar for Russian team 10. Russian team 2 pts. 8,694
  1. Avatar for retiredmichael 11. retiredmichael Lv 1 74 pts. 10,376
  2. Avatar for markm457 12. markm457 Lv 1 72 pts. 10,310
  3. Avatar for bertro 13. bertro Lv 1 70 pts. 10,288
  4. Avatar for Bletchley Park 14. Bletchley Park Lv 1 68 pts. 10,283
  5. Avatar for Bruno Kestemont 15. Bruno Kestemont Lv 1 66 pts. 10,279
  6. Avatar for actiasluna 16. actiasluna Lv 1 64 pts. 10,271
  7. Avatar for MurloW 17. MurloW Lv 1 62 pts. 10,253
  8. Avatar for hpaege 18. hpaege Lv 1 60 pts. 10,238
  9. Avatar for Galaxie 19. Galaxie Lv 1 58 pts. 10,192
  10. Avatar for Deleted player 20. Deleted player pts. 10,187

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

Residue Count: Penalizes extra residues inserted beyond the 85 residue limit. Players may insert up to 10 extra residues.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."

Bletchley Park Lv 1

Can we please have a policy decision on what to do with this puzzle ? Should we try to make 70-residue designs (and not know how we really score) or go for the 85 residue possibility ?

This is relevant in case the puzzle does NOT get invalidated for the 85 residue solutions. Anyone working on a 70 design will get penalized in points.

You might consider leaving the 85 residues as valid and treating the puzzle as such, then repost the puzzle with a sufficient penalty for the excess 15 residues to allow reloading the current solutions including 70 residue ones in the new puzzle with a new residue count filter.

gitwut Lv 1

To be fair to everyone, the puzzle should just be closed with zero points. I, for one, did not think using the extra 15 residues was an ethical thing for me to do. Not criticizing anyone who did, as I understand that others might not share my opinion. :P<p>
The puzzle can then be re-issued with consistent filters.

spvincent Lv 1

I'd like to see design puzzles have arbitrary length, with scoring scaled according to the number of residues. Small designs could then compete on a fair basis with large ones, and there'd be no reason to distort a design by having to squeeze in extra residues in places where they don't really fit (and the converse).

inkycatz Lv 1

Thanks for the feedback. I've boosted this thread to the team and hope to have some word back on it soon.

bkoep Staff Lv 1

Hi all, sorry for the delayed response to this—we were running a little short-handed last week. Since this puzzle is scheduled to close in the next 24 hours, we won't take any immediate action. The puzzle will close as scheduled and will be scored normally.

We apologize to any players who feel disadvantaged by the erroneous Residue Count filter. However, I would encourage those players to share their solutions using the "Share with Scientists" feature—we are still very interested in your work!

So that all players will have a chance to compete with their work on this puzzle, solutions from Puzzle 1302 will be accessible in two future puzzles. Over the next two weeks, we'll follow up with (corrected) 70 and 85 residue design puzzles. For both future puzzles, players will be able to load in solutions from Puzzle 1302.

markm457 Lv 1

Is this a change in policy?

In the past, flawed puzzles were always closed without score/rank and reissued with the ability to load saves. It seems to set a bad precedent to score puzzles that do not have a level playing field due to either flawed construction and/or a lack of communication.

TomTaylor Lv 1

I was aware of the mistake with 85 residues early on. Since there was an 85 residue puzzle a few weeks earlier I assumed this was a mistake that would be justly fixed and created 70 residue solutions.

I'll take into account your policy of rewarding players who game the system for new puzzles. You've opened up a can of worms.