1357: Electron Density Practice: Trypsin Inhibitor
Closed since almost 9 years ago
Intermediate Overall Prediction Electron DensitySummary
- Created
- March 24, 2017
- Expires
- Max points
- 100
This puzzle is meant for Foldit players to practice folding a protein with an electron density map. This electron density map was generated from x-ray diffraction at a resolution of 1.5 Å, and was published in 1983. The protein is an inhibitor of trypsin, an enzyme whose role it is to break down other proteins. This protein includes six cysteines that oxidize to form three disulfide bonds. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!
Sequence:
RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA
