Placeholder image of a protein
Icon representing a puzzle

1401: Small Monomer Design: Larger Core

Closed since over 8 years ago

Intermediate Overall Prediction

Summary

Created
July 07, 2017
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 65-75 residues. The Core Existence filter has been escalated so that 35% of residues need to be buried in the protein core. The starting structure has 65 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Go Science
    1. Go Science
    100 pts. 10,208
  2. Avatar for Beta Folders 2. Beta Folders 71 pts. 10,206
  3. Avatar for Anthropic Dreams 3. Anthropic Dreams 49 pts. 10,155
  4. Avatar for Gargleblasters 4. Gargleblasters 33 pts. 10,147
  5. Avatar for Contenders 5. Contenders 22 pts. 10,127
  6. Avatar for Marvin's bunch 6. Marvin's bunch 14 pts. 9,998
  7. Avatar for Void Crushers 7. Void Crushers 8 pts. 9,870
  8. Avatar for L'Alliance Francophone 8. L'Alliance Francophone 5 pts. 9,480
  9. Avatar for HMT heritage 9. HMT heritage 3 pts. 8,997
  10. Avatar for Italiani Al Lavoro 10. Italiani Al Lavoro 2 pts. 8,935
  1. Avatar for Pibeagles 91. Pibeagles Lv 1 1 pt. 4,523
  2. Avatar for Erica_W 92. Erica_W Lv 1 1 pt. 4,341
  3. Avatar for molleke 93. molleke Lv 1 1 pt. 4,178
  4. Avatar for arlettelh97 94. arlettelh97 Lv 1 1 pt. 4,112
  5. Avatar for NotJim99 95. NotJim99 Lv 1 1 pt. 3,613
  6. Avatar for fujioyama 96. fujioyama Lv 1 1 pt. 3,612
  7. Avatar for Giantbluefish 97. Giantbluefish Lv 1 1 pt. 3,611
  8. Avatar for mhero10 98. mhero10 Lv 1 1 pt. 3,609
  9. Avatar for hansvandenhof 99. hansvandenhof Lv 1 1 pt. 3,609
  10. Avatar for Radeodem8 100. Radeodem8 Lv 1 1 pt. 0

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 35% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 65. Players may use up to 75 residues in total.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."

gitwut Lv 1

This puzzle does not show up on the client Puzzles menu. I also received no new puzzle Notification on any of the 4 clients I have open and running.

Susume Lv 1

You may have to accept the latest update before this puzzle shows up in your list.