Placeholder image of a protein
Icon representing a puzzle

1514: Revisiting Puzzle 62: Halorhodopsin

Closed since almost 8 years ago

Intermediate Overall Prediction

Summary

Created
April 29, 2018
Expires
Max points
100
Description

This is a throwback puzzle to the early days of Foldit. This protein is able to absorb light and use the energy to transfer chloride ions across the cell membrane. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.



Sequence:


RENALLSSSLWVNVALAGIAILVFVYMGRTIRPGRPRLIWGATLMIPLVSISSYLGLLSGLTVGMIEMPAGHALAGEMVRSQWGRYLTWALSTPMILLALGLLADVDLGSLFTVIAADIGMCVTGLAAAMTTSALLFRWAFYAISCAFFVVVLSALVTDWAASASSAGTAEIFDTLRVLTVVLWLGYPIVWAVGVEGLALVQSVGATSWAYSVLDVFAKYVFAFILLRWVANNERTVAV

Top groups

  1. Avatar for freefolder 11. freefolder 1 pt. 13,847
  2. Avatar for Trinity Biology 12. Trinity Biology 1 pt. 12,974
  3. Avatar for Deleted group 13. Deleted group pts. 12,938
  4. Avatar for foldeRNA 14. foldeRNA 1 pt. 9,403
  5. Avatar for Kangwon_National_University_Computers_in_Chemistry 15. Kangwon_National_University_Computers_in_Chemistry 1 pt. 7,647
  6. Avatar for UZBioinformatics2018 16. UZBioinformatics2018 1 pt. 7,512
  1. Avatar for Galaxie
    1. Galaxie Lv 1
    100 pts. 15,586
  2. Avatar for hpaege 2. hpaege Lv 1 97 pts. 15,564
  3. Avatar for LociOiling 3. LociOiling Lv 1 94 pts. 15,550
  4. Avatar for actiasluna 4. actiasluna Lv 1 91 pts. 15,512
  5. Avatar for Bruno Kestemont 5. Bruno Kestemont Lv 1 87 pts. 15,470
  6. Avatar for alcor29 6. alcor29 Lv 1 84 pts. 15,427
  7. Avatar for ZeroLeak7 7. ZeroLeak7 Lv 1 81 pts. 15,403
  8. Avatar for frood66 8. frood66 Lv 1 78 pts. 15,384
  9. Avatar for Bletchley Park 9. Bletchley Park Lv 1 76 pts. 15,334
  10. Avatar for reefyrob 10. reefyrob Lv 1 73 pts. 15,319

Comments

carsonfb Lv 1

I am running Windows 10 Pro 64-bit and the puzzle crashes on my when frequently when I "wiggle sidechains" or run any script that utilizes that feature.

I have 16GB of RAM with ~20% free when it crashes, so I don't believe memory is an issue. Also, I only run one client at a time.

LociOiling Lv 1

The crashing on high wiggle power seems to have something to do with undo.

Still early on, but in Undo -> Graph Properties, setting "Memory Usage" to 0% seems to have eliminated the quick crashes I was seeing before on several recipes.

Even without these changes, some recipes seemed invulnerable to the problem. For example, Microidealize 4.0 ran to completion where similar idealize recipes crashed. Microidealize uses quicksave and quickload only, and avoids the recentbest functions.

Other recipes which were adapted for Sketchbook puzzles were also much less crashy. These recipes tend to do a quickload if there's no gain or a small gain.

LociOiling Lv 1

In Undo -> Graph Properties, I had already set Max Graph Length to 25, which didn't prevent the crashes.

toshiue Lv 1

Crashes on most anything I use on it at high CI setting. Has crashed both my i7 and i9, both 64bit. crashed not the client alone but the machine on the i9 down for 2 days now. Will not get past the POST. More than ample memory and space on both machines. i7 crashes only client, but instantly. None of the workarounds are having any effect. With respect, this is not a level playing field. The puzzle should be withdrawn please.