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1515: Medium Monomer Design

Closed since almost 8 years ago

Intermediate

Summary

Created
April 29, 2018
Expires
Max points
100
Description

Note: This puzzle was closed early due to an erroneous Residue Count Filter, and reposted as Puzzle 1515b. Players may load their work from this puzzle into the reposted puzzle.



This puzzle challenges players to design a single-chain protein with 75-90 residues. The starting structure has 75 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

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Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 75, at a cost of 32 points per residue. Players may use up to 90 residues in total.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."

LociOiling Lv 1

The puzzle starts with 75 residues, but it also starts with a residue count penalty of -320 points.

You cut this puzzle down to 65 residues if desired, but it can also be expanded to 90 residues as stated.