Beginner Puzzle (<150): Docking Design

Closed since about 7 years ago

Summary

• Created: January 27, 2014
• Expires: February 07, 2019 at 23:00 UTC
• Max points: 100

Description

We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.



START HERE:

If you are new to Foldit, here are detailed instructions to get you started:

http://fold.it/portal/node/988864

_____________________________

If you want to fold proteins, know that there are many ways to play and this variety is the main value of Foldit :

- try all puzzles not only "Beginners" ones,

- fold first the ones you like the most,

- try it by yourself to understand what works and what doesn't,

- ask for tips in global chat when you think you don't understand something.

Make sure you have followed these tutorials:

- Lonely Sheets,

- Lock and Lower,

- Rebuild,

- Structure and Rebuild,

- Movin' Along,

- Control over Clashing,

- Intro to Design,

- Swappin' Sidechains,

- Mass Mutate,

- Insertion and Deletion

before starting this puzzle.

Top groups

• 1. Marvin's bunch 100 pts. 10,370
• 2. CS 234 80 pts. 10,295
• 3. Go Science 63 pts. 10,281
• 4. BIOC 402 49 pts. 10,277
• 5. Deleted group pts. 10,250
• 6. Anthropic Dreams 28 pts. 10,246
• 7. Gargleblasters 21 pts. 10,231
• 8. Coastal Biochemistry 15 pts. 10,211
• 9. FoldIt@Poland 11 pts. 10,209
• 10. DW 2020 8 pts. 10,175

Top soloists

• 71. boiled 41 pts. 10,173
• 72. sndavis 40 pts. 10,173
• 73. Savas 40 pts. 10,171
• 74. zysiolo 39 pts. 10,170
• 75. mirjamvandelft 39 pts. 10,169
• 76. CB19Peck 38 pts. 10,162
• 77. MeganLe 37 pts. 10,161
• 78. Anit371 37 pts. 10,159
• 79. BlackyAlex 36 pts. 10,159
• 80. jaredmason24 36 pts. 10,158