Beginner Puzzle (<150): Docking Design

Closed since almost 7 years ago

Summary

• Created: January 27, 2014
• Expires: June 13, 2019 at 23:00 UTC
• Max points: 100

Description

We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.



START HERE:

If you are new to Foldit, here are detailed instructions to get you started:

http://fold.it/portal/node/988864

_____________________________

If you want to fold proteins, know that there are many ways to play and this variety is the main value of Foldit :

- try all puzzles not only "Beginners" ones,

- fold first the ones you like the most,

- try it by yourself to understand what works and what doesn't,

- ask for tips in global chat when you think you don't understand something.

Make sure you have followed these tutorials:

- Lonely Sheets,

- Lock and Lower,

- Rebuild,

- Structure and Rebuild,

- Movin' Along,

- Control over Clashing,

- Intro to Design,

- Swappin' Sidechains,

- Mass Mutate,

- Insertion and Deletion

before starting this puzzle.

Top groups

• 11. Void Crushers 2 pts. 10,060
• 12. Go Science 1 pt. 10,057
• 13. GENE 433 1 pt. 10,052
• 14. BSM4601 1 pt. 9,978
• 15. CH4110 Fold it! 1 pt. 9,930
• 16. Beta Folders 1 pt. 9,909
• 17. 2z BT 2017/18 1 pt. 9,768
• 18. Window Group 1 pt. 9,359
• 19. CMB Protein Folding Game 2019 1 pt. 8,149

Top soloists

• 11. Jeoson J 86 pts. 10,308
• 12. P450monooxygenase 85 pts. 10,307
• 13. kentish_alex 83 pts. 10,307
• 14. nagyzs 82 pts. 10,304
• 15. zsumierp 81 pts. 10,301
• 16. dd-2 79 pts. 10,300
• 17. Beowolf Tailchaser 78 pts. 10,295
• 18. rwillett 77 pts. 10,292
• 19. nadinelim 75 pts. 10,289
• 20. Wipf 74 pts. 10,288