Placeholder image of a protein
Icon representing a puzzle

Beginner Puzzle (<150): Docking Design

Closed since over 6 years ago

Beginner Beginner

Summary

Created
January 27, 2014
Expires
Max points
100
Description

We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.



START HERE:

If you are new to Foldit, here are detailed instructions to get you started:

http://fold.it/portal/node/988864

_____________________________


If you want to fold proteins, know that there are many ways to play and this variety is the main value of Foldit :

- try all puzzles not only "Beginners" ones,

- fold first the ones you like the most,

- try it by yourself to understand what works and what doesn't,

- ask for tips in global chat when you think you don't understand something.


Make sure you have followed these tutorials:

- Lonely Sheets,

- Lock and Lower,

- Rebuild,

- Structure and Rebuild,

- Movin' Along,

- Control over Clashing,

- Intro to Design,

- Swappin' Sidechains,

- Mass Mutate,

- Insertion and Deletion


before starting this puzzle.

Top groups

  1. Avatar for Void Crushers
    1. Void Crushers
    100 pts. 10,303
  2. Avatar for Coastal Biochemistry 2. Coastal Biochemistry 86 pts. 10,291
  3. Avatar for Deleted group 3. Deleted group pts. 10,278
  4. Avatar for Czech National Team 4. Czech National Team 62 pts. 10,271
  5. Avatar for Boise State Drug Discovery and Design Class 5. Boise State Drug Discovery and Design Class 52 pts. 10,254
  6. Avatar for Contenders 6. Contenders 43 pts. 10,228
  7. Avatar for MTU CM4710 2019 7. MTU CM4710 2019 36 pts. 10,223
  8. Avatar for Trinity Biology 8. Trinity Biology 30 pts. 10,221
  9. Avatar for bioinforockers 9. bioinforockers 24 pts. 10,200
  10. Avatar for Biochem 1090 FS2019 10. Biochem 1090 FS2019 20 pts. 10,196
  1. Avatar for fosfotrinucleotide 31. fosfotrinucleotide Lv 1 69 pts. 10,234
  2. Avatar for jherbert 32. jherbert Lv 1 68 pts. 10,231
  3. Avatar for Erin_M 33. Erin_M Lv 1 67 pts. 10,230
  4. Avatar for marcdmc 34. marcdmc Lv 1 67 pts. 10,229
  5. Avatar for zsong 35. zsong Lv 1 66 pts. 10,228
  6. Avatar for martinzblavy 36. martinzblavy Lv 1 65 pts. 10,228
  7. Avatar for krstiger 37. krstiger Lv 1 64 pts. 10,227
  8. Avatar for ddd_Marquart 38. ddd_Marquart Lv 1 63 pts. 10,227
  9. Avatar for ddd_olsen 39. ddd_olsen Lv 1 62 pts. 10,226
  10. Avatar for zavdielx 40. zavdielx Lv 1 62 pts. 10,224

Comments