Beginner Puzzle (<150): Docking Design

Closed since over 6 years ago

Summary

• Created: January 27, 2014
• Expires: November 28, 2019 at 23:00 UTC
• Max points: 100

Description

We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.



START HERE:

If you are new to Foldit, here are detailed instructions to get you started:

http://fold.it/portal/node/988864

_____________________________

If you want to fold proteins, know that there are many ways to play and this variety is the main value of Foldit :

- try all puzzles not only "Beginners" ones,

- fold first the ones you like the most,

- try it by yourself to understand what works and what doesn't,

- ask for tips in global chat when you think you don't understand something.

Make sure you have followed these tutorials:

- Lonely Sheets,

- Lock and Lower,

- Rebuild,

- Structure and Rebuild,

- Movin' Along,

- Control over Clashing,

- Intro to Design,

- Swappin' Sidechains,

- Mass Mutate,

- Insertion and Deletion

before starting this puzzle.

Top groups

• 11. Ukraine 8 pts. 10,111
• 12. Trinity Biology 6 pts. 10,086
• 13. STME 1903 4 pts. 10,060
• 14. GUGITBIOTECH 3 pts. 10,045
• 15. Gargleblasters 2 pts. 10,021
• 16. CGS Honors Biology 2022-23 2 pts. 9,995
• 17. BMBFA19 1 pt. 9,971
• 18. Beta Folders 1 pt. 9,963
• 19. Dutch Power Cows 1 pt. 9,910
• 20. Wooster BIOL 201 Leslie 1 pt. 9,823

Top soloists

• 31. PakElgaard 63 pts. 10,240
• 32. 8fold 62 pts. 10,240
• 33. mbastion 61 pts. 10,239
• 34. cdugger 60 pts. 10,235
• 35. quack17 59 pts. 10,234
• 36. xythus 58 pts. 10,234
• 37. atanas.atanasov 57 pts. 10,233
• 38. KimJongUn 56 pts. 10,229
• 39. tamanrasset 55 pts. 10,228
• 40. BrSch2019 54 pts. 10,227