Beginner Puzzle (<150): Docking Design

Closed since over 6 years ago

Summary

• Created: January 27, 2014
• Expires: November 28, 2019 at 23:00 UTC
• Max points: 100

Description

We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.



START HERE:

If you are new to Foldit, here are detailed instructions to get you started:

http://fold.it/portal/node/988864

_____________________________

If you want to fold proteins, know that there are many ways to play and this variety is the main value of Foldit :

- try all puzzles not only "Beginners" ones,

- fold first the ones you like the most,

- try it by yourself to understand what works and what doesn't,

- ask for tips in global chat when you think you don't understand something.

Make sure you have followed these tutorials:

- Lonely Sheets,

- Lock and Lower,

- Rebuild,

- Structure and Rebuild,

- Movin' Along,

- Control over Clashing,

- Intro to Design,

- Swappin' Sidechains,

- Mass Mutate,

- Insertion and Deletion

before starting this puzzle.

Top groups

• 1. FoldIt@Netherlands 100 pts. 10,350
• 2. Void Crushers 82 pts. 10,319
• 3. Biology 2 66 pts. 10,294
• 4. Go Science 53 pts. 10,271
• 5. Marvin's bunch 42 pts. 10,265
• 6. Eὕρηκα! Heureka! 33 pts. 10,203
• 7. Team China 26 pts. 10,126
• 8. L'Alliance Francophone 20 pts. 10,125
• 9. Freeport Honors Biology 15 pts. 10,124
• 10. Deleted group pts. 10,122

Top soloists

• 71. narutofan678 32 pts. 10,157
• 72. RoccOblivion 31 pts. 10,148
• 73. Cooki3Girl123 30 pts. 10,148
• 74. spencerclark 30 pts. 10,148
• 75. Seikarii 29 pts. 10,147
• 76. noxrenge 29 pts. 10,146
• 77. BaileyBugW 28 pts. 10,143
• 78. Joryell 28 pts. 10,139
• 79. gracejhsn 27 pts. 10,134
• 80. bolloforbio 27 pts. 10,131