Placeholder image of a protein
Icon representing a puzzle

Beginner Puzzle (<150): Coronavirus

Closed since almost 6 years ago

Beginner Beginner

Summary

Created
March 03, 2020
Expires
Max points
100
Description

Design a protein binder against coronavirus! The starting structure shows how the coronavirus spike protein binds to a human receptor protein. The coronavirus protein (in gray) is mostly frozen, except for the orange and blue sidechains at the binding site. The binding site of coronavirus sticks to the human protein (in color), and this allows the coronavirus to infect human cells. We want to design a new protein that can bind to coronavirus more tightly than the human protein! A tight binder could block the normal coronavirus-human interaction, and might be used as an antiviral drug against coronavirus! Refold and mutate the starting structure to increase your score and improve binding against coronavirus!



START HERE:

If you are new to Foldit, here are detailed instructions to get you started:

http://fold.it/portal/node/988864

_____________________________


If you want to fold proteins, know that there are many ways to play and this variety is the main value of Foldit :

- try all puzzles not only "Beginners" ones,

- fold first the ones you like the most,

- try it by yourself to understand what works and what doesn't,

- ask for tips in global chat when you think you don't understand something.

Top groups

  1. Avatar for Team India
    1. Team India
    100 pts. 13,879
  2. Avatar for Go Science 2. Go Science 96 pts. 13,837
  3. Avatar for Beta Folders 3. Beta Folders 92 pts. 13,744
  4. Avatar for Gargleblasters 4. Gargleblasters 88 pts. 13,675
  5. Avatar for SHELL 5. SHELL 84 pts. 13,610
  6. Avatar for Italiani Al Lavoro 6. Italiani Al Lavoro 80 pts. 13,491
  7. Avatar for Anthropic Dreams 7. Anthropic Dreams 77 pts. 13,457
  8. Avatar for Deleted group 8. Deleted group pts. 13,438
  9. Avatar for Team China 9. Team China 70 pts. 13,430
  10. Avatar for SHELL 2 10. SHELL 2 67 pts. 13,429
  1. Avatar for jimweng 1211. jimweng Lv 1 51 pts. 12,991
  2. Avatar for Kingeeee 1212. Kingeeee Lv 1 51 pts. 12,991
  3. Avatar for David Windsor 1213. David Windsor Lv 1 51 pts. 12,991
  4. Avatar for qsef1256 1214. qsef1256 Lv 1 51 pts. 12,991
  5. Avatar for murshid 1215. murshid Lv 1 51 pts. 12,991
  6. Avatar for Slothmaster55 1216. Slothmaster55 Lv 1 51 pts. 12,991
  7. Avatar for Kajtson 1217. Kajtson Lv 1 51 pts. 12,991
  8. Avatar for jmwhyte 1218. jmwhyte Lv 1 51 pts. 12,991
  9. Avatar for nguyenbn 1219. nguyenbn Lv 1 51 pts. 12,991
  10. Avatar for RedKamel 1220. RedKamel Lv 1 51 pts. 12,991

Comments

bkoep Staff Lv 1

The solutions from this Beginner puzzle are incompatible with other non-Beginner puzzles,. Players may not load solutions from this puzzle into other coronavirus puzzles.