Placeholder image of a protein
Icon representing a puzzle

Beginner Puzzle (<150): Coronavirus

Closed since almost 6 years ago

Beginner Beginner

Summary

Created
March 03, 2020
Expires
Max points
100
Description

Design a protein binder against coronavirus! The starting structure shows how the coronavirus spike protein binds to a human receptor protein. The coronavirus protein (in gray) is mostly frozen, except for the orange and blue sidechains at the binding site. The binding site of coronavirus sticks to the human protein (in color), and this allows the coronavirus to infect human cells. We want to design a new protein that can bind to coronavirus more tightly than the human protein! A tight binder could block the normal coronavirus-human interaction, and might be used as an antiviral drug against coronavirus! Refold and mutate the starting structure to increase your score and improve binding against coronavirus!



START HERE:

If you are new to Foldit, here are detailed instructions to get you started:

http://fold.it/portal/node/988864

_____________________________


If you want to fold proteins, know that there are many ways to play and this variety is the main value of Foldit :

- try all puzzles not only "Beginners" ones,

- fold first the ones you like the most,

- try it by yourself to understand what works and what doesn't,

- ask for tips in global chat when you think you don't understand something.

Top groups

  1. Avatar for Team India
    1. Team India
    100 pts. 13,879
  2. Avatar for Go Science 2. Go Science 96 pts. 13,837
  3. Avatar for Beta Folders 3. Beta Folders 92 pts. 13,744
  4. Avatar for Gargleblasters 4. Gargleblasters 88 pts. 13,675
  5. Avatar for SHELL 5. SHELL 84 pts. 13,610
  6. Avatar for Italiani Al Lavoro 6. Italiani Al Lavoro 80 pts. 13,491
  7. Avatar for Anthropic Dreams 7. Anthropic Dreams 77 pts. 13,457
  8. Avatar for Deleted group 8. Deleted group pts. 13,438
  9. Avatar for Team China 9. Team China 70 pts. 13,430
  10. Avatar for SHELL 2 10. SHELL 2 67 pts. 13,429
  1. Avatar for stasik1402 691. stasik1402 Lv 1 69 pts. 13,043
  2. Avatar for Pope Urban II 692. Pope Urban II Lv 1 69 pts. 13,042
  3. Avatar for knarzelwicht 693. knarzelwicht Lv 1 69 pts. 13,042
  4. Avatar for juliamaus87 694. juliamaus87 Lv 1 69 pts. 13,042
  5. Avatar for Mr_Pink78 695. Mr_Pink78 Lv 1 69 pts. 13,042
  6. Avatar for sanjaysaharan123 696. sanjaysaharan123 Lv 1 69 pts. 13,041
  7. Avatar for Morkian 697. Morkian Lv 1 69 pts. 13,041
  8. Avatar for KSword Wei 698. KSword Wei Lv 1 69 pts. 13,041
  9. Avatar for Thilos 699. Thilos Lv 1 69 pts. 13,041
  10. Avatar for Dunga 700. Dunga Lv 1 69 pts. 13,040

Comments

bkoep Staff Lv 1

The solutions from this Beginner puzzle are incompatible with other non-Beginner puzzles,. Players may not load solutions from this puzzle into other coronavirus puzzles.