Placeholder image of a protein
Icon representing a puzzle

Protein Design Sandbox

Closed since about 4 years ago

Beginner Beginner

Summary

Created
March 22, 2020
Expires
Max points
100
Description

Experiment with protein design! We've disabled many of the restrictions in normal Science puzzles, so players have access to all protein designs tools, and may insert and delete any number of residues. Foldit scientists do not check the solutions from this puzzle, and playing this puzzle will not affect your global or category rankings.



Two common protein design Objectives are available, but they will not award any bonuses or penalties. The Core Existence Objective checks to see if 30% of residues are buried in the protein core, away from the water surrounding the protein. The Ideal Loops Objective looks for loops with problematic backbone folds. If you build an especially large protein, try disabling these Objectives to improve Foldit's performance.

Top groups

  1. Avatar for Void Crushers 11. Void Crushers 55 pts. 21,009
  2. Avatar for Marvin's bunch 12. Marvin's bunch 51 pts. 16,030
  3. Avatar for Hold My Beer 13. Hold My Beer 48 pts. 14,536
  4. Avatar for L'Alliance Francophone 14. L'Alliance Francophone 45 pts. 14,160
  5. Avatar for CHNO Junkies 15. CHNO Junkies 42 pts. 12,927
  6. Avatar for AlphaFold 16. AlphaFold 39 pts. 10,686
  7. Avatar for Herobrine's Army 17. Herobrine's Army 37 pts. 10,674
  8. Avatar for Team South Africa 18. Team South Africa 34 pts. 10,649
  9. Avatar for Ogre's lab 19. Ogre's lab 32 pts. 10,573
  10. Avatar for FoldIt@Netherlands 20. FoldIt@Netherlands 30 pts. 10,568
  1. Avatar for Pyxicephalus 371. Pyxicephalus Lv 1 25 pts. 9,175
  2. Avatar for okaits7534 372. okaits7534 Lv 1 25 pts. 9,173
  3. Avatar for boccaccio 373. boccaccio Lv 1 25 pts. 9,160
  4. Avatar for alt52 374. alt52 Lv 1 25 pts. 9,157
  5. Avatar for jacob_n 375. jacob_n Lv 1 25 pts. 9,156
  6. Avatar for sherlomck_7 376. sherlomck_7 Lv 1 25 pts. 9,154
  7. Avatar for PseudoMathematician 377. PseudoMathematician Lv 1 25 pts. 9,149
  8. Avatar for papasmurf01 378. papasmurf01 Lv 1 25 pts. 9,147
  9. Avatar for Anny 8324 379. Anny 8324 Lv 1 24 pts. 9,138
  10. Avatar for kurenan 380. kurenan Lv 1 24 pts. 9,132

Comments

DoctorSockrates Lv 1

I was wondering when something like this would turn up. Glad to see an unrestricted proving ground for future projects.

KALYPSO Lv 1

Soap,,,,breaks the faty around the cell ,,,hmmmmm,,,puzzle that,,,just saying,,,try it

Bautho Lv 1

I don't know what is / I did wrong, but I designed a fold - perfectly fine, but after a while I wiggled, and one part of the protein will start to unfold (the helix is not a helix anymore) and the score goes down instead of up.
I sent the structure to scientists - if you could reproduce that behavior would be interesting! :)