Placeholder image of a protein
Icon representing a puzzle

Protein Design Sandbox

Closed since about 4 years ago

Beginner

Summary

Created
March 22, 2020
Expires
Max points
100
Description

Experiment with protein design! We've disabled many of the restrictions in normal Science puzzles, so players have access to all protein designs tools, and may insert and delete any number of residues. Foldit scientists do not check the solutions from this puzzle, and playing this puzzle will not affect your global or category rankings.



Two common protein design Objectives are available, but they will not award any bonuses or penalties. The Core Existence Objective checks to see if 30% of residues are buried in the protein core, away from the water surrounding the protein. The Ideal Loops Objective looks for loops with problematic backbone folds. If you build an especially large protein, try disabling these Objectives to improve Foldit's performance.

Top groups

  1. Avatar for Olsztynek 21. Olsztynek 28 pts. 10,548
  2. Avatar for SOU Biochemistry CH455 (2020) 22. SOU Biochemistry CH455 (2020) 26 pts. 10,532
  3. Avatar for SETI.Germany 23. SETI.Germany 24 pts. 10,454
  4. Avatar for Rechenkraft.net 24. Rechenkraft.net 22 pts. 10,406
  5. Avatar for Coastal Biochemistry 25. Coastal Biochemistry 20 pts. 10,295
  6. Avatar for Foldit Staff 26. Foldit Staff 19 pts. 10,249
  7. Avatar for Italiani Al Lavoro 27. Italiani Al Lavoro 17 pts. 10,161
  8. Avatar for NMHU Biol4230 Spr 20 28. NMHU Biol4230 Spr 20 16 pts. 9,861
  9. Avatar for Deleted group 29. Deleted group pts. 9,846
  10. Avatar for GENE 433 30. GENE 433 14 pts. 9,732
  1. Avatar for krw- 621. krw- Lv 1 8 pts. 7,492
  2. Avatar for Mike Lewis 622. Mike Lewis Lv 1 8 pts. 7,484
  3. Avatar for rmusallam 623. rmusallam Lv 1 8 pts. 7,465
  4. Avatar for devjosh 624. devjosh Lv 1 8 pts. 7,464
  5. Avatar for manf 625. manf Lv 1 8 pts. 7,449
  6. Avatar for pmthomson90 626. pmthomson90 Lv 1 8 pts. 7,415
  7. Avatar for Serca 627. Serca Lv 1 8 pts. 7,387
  8. Avatar for JStocke12 628. JStocke12 Lv 1 7 pts. 7,352
  9. Avatar for wolna prawda 629. wolna prawda Lv 1 7 pts. 7,244
  10. Avatar for celinae 630. celinae Lv 1 7 pts. 7,153

Comments

DoctorSockrates Lv 1

I was wondering when something like this would turn up. Glad to see an unrestricted proving ground for future projects.

KALYPSO Lv 1

Soap,,,,breaks the faty around the cell ,,,hmmmmm,,,puzzle that,,,just saying,,,try it

Bautho Lv 1

I don't know what is / I did wrong, but I designed a fold - perfectly fine, but after a while I wiggled, and one part of the protein will start to unfold (the helix is not a helix anymore) and the score goes down instead of up.
I sent the structure to scientists - if you could reproduce that behavior would be interesting! :)