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Protein Design Sandbox

Closed since about 4 years ago

Beginner

Summary

Created
March 22, 2020
Expires
Max points
100
Description

Experiment with protein design! We've disabled many of the restrictions in normal Science puzzles, so players have access to all protein designs tools, and may insert and delete any number of residues. Foldit scientists do not check the solutions from this puzzle, and playing this puzzle will not affect your global or category rankings.



Two common protein design Objectives are available, but they will not award any bonuses or penalties. The Core Existence Objective checks to see if 30% of residues are buried in the protein core, away from the water surrounding the protein. The Ideal Loops Objective looks for loops with problematic backbone folds. If you build an especially large protein, try disabling these Objectives to improve Foldit's performance.

Top groups

  1. Avatar for SHELL 71. SHELL 1 pt. 0
  2. Avatar for foldeRNA 72. foldeRNA 1 pt. 0
  3. Avatar for test_group1 73. test_group1 1 pt. 0
  4. Avatar for Minions of TWIS 74. Minions of TWIS 1 pt. 0
  5. Avatar for DSN @ Home 75. DSN @ Home 1 pt. 0
  6. Avatar for Genetics 1 76. Genetics 1 1 pt. 0
  7. Avatar for BC125_Buco,Palisoc,Torre 77. BC125_Buco,Palisoc,Torre 1 pt. 0
  8. Avatar for Window Group 78. Window Group 1 pt. 0
  9. Avatar for BioCentric 79. BioCentric 1 pt. 0
  10. Avatar for MTS - Proteins 80. MTS - Proteins 1 pt. 0
  1. Avatar for freethought78 211. freethought78 Lv 1 48 pts. 10,140
  2. Avatar for aqsw 212. aqsw Lv 1 48 pts. 10,140
  3. Avatar for TurnerK25 213. TurnerK25 Lv 1 48 pts. 10,136
  4. Avatar for irohato 214. irohato Lv 1 47 pts. 10,130
  5. Avatar for Hustvedt 215. Hustvedt Lv 1 47 pts. 10,118
  6. Avatar for rlee287 216. rlee287 Lv 1 47 pts. 10,118
  7. Avatar for fearjuan 217. fearjuan Lv 1 47 pts. 10,117
  8. Avatar for Linde42 218. Linde42 Lv 1 47 pts. 10,101
  9. Avatar for keenanpepper 219. keenanpepper Lv 1 47 pts. 10,099
  10. Avatar for pascal ochem 220. pascal ochem Lv 1 46 pts. 10,074

Comments

DoctorSockrates Lv 1

I was wondering when something like this would turn up. Glad to see an unrestricted proving ground for future projects.

KALYPSO Lv 1

Soap,,,,breaks the faty around the cell ,,,hmmmmm,,,puzzle that,,,just saying,,,try it

Bautho Lv 1

I don't know what is / I did wrong, but I designed a fold - perfectly fine, but after a while I wiggled, and one part of the protein will start to unfold (the helix is not a helix anymore) and the score goes down instead of up.
I sent the structure to scientists - if you could reproduce that behavior would be interesting! :)