Placeholder image of a protein
Icon representing a puzzle

Protein Design Sandbox

Closed since about 4 years ago

Beginner

Summary

Created
March 22, 2020
Expires
Max points
100
Description

Experiment with protein design! We've disabled many of the restrictions in normal Science puzzles, so players have access to all protein designs tools, and may insert and delete any number of residues. Foldit scientists do not check the solutions from this puzzle, and playing this puzzle will not affect your global or category rankings.



Two common protein design Objectives are available, but they will not award any bonuses or penalties. The Core Existence Objective checks to see if 30% of residues are buried in the protein core, away from the water surrounding the protein. The Ideal Loops Objective looks for loops with problematic backbone folds. If you build an especially large protein, try disabling these Objectives to improve Foldit's performance.

Top groups

  1. Avatar for TEA 81. TEA 1 pt. 0
  2. Avatar for we can is can 82. we can is can 1 pt. 0
  3. Avatar for FRS 004-18 & 004-28 UC Davis, 202003 83. FRS 004-18 & 004-28 UC Davis, 202003 1 pt. 0
  4. Avatar for Macromolecules@MQ 2020 84. Macromolecules@MQ 2020 1 pt. 0
  5. Avatar for UPJ Biochem 25 85. UPJ Biochem 25 1 pt. 0
  6. Avatar for WSU_CHEM666_Fall2020 86. WSU_CHEM666_Fall2020 1 pt. 0
  7. Avatar for Mann Fall 2020 CHEM324 87. Mann Fall 2020 CHEM324 1 pt. 0
  8. Avatar for SWHS AP Biology 88. SWHS AP Biology 1 pt. 0
  1. Avatar for n98 541. n98 Lv 1 12 pts. 8,244
  2. Avatar for phshi2022 542. phshi2022 Lv 1 12 pts. 8,239
  3. Avatar for squid233 543. squid233 Lv 1 12 pts. 8,229
  4. Avatar for kimjunhee 544. kimjunhee Lv 1 11 pts. 8,223
  5. Avatar for kotenok2000 545. kotenok2000 Lv 1 11 pts. 8,205
  6. Avatar for HumanoidCPU 546. HumanoidCPU Lv 1 11 pts. 8,149
  7. Avatar for 928fej9m8jwamec 547. 928fej9m8jwamec Lv 1 11 pts. 8,147
  8. Avatar for bolloforbio 548. bolloforbio Lv 1 11 pts. 8,147
  9. Avatar for wontonsoup234 549. wontonsoup234 Lv 1 11 pts. 8,145
  10. Avatar for Chiaroscuro2 550. Chiaroscuro2 Lv 1 11 pts. 8,145

Comments

DoctorSockrates Lv 1

I was wondering when something like this would turn up. Glad to see an unrestricted proving ground for future projects.

KALYPSO Lv 1

Soap,,,,breaks the faty around the cell ,,,hmmmmm,,,puzzle that,,,just saying,,,try it

Bautho Lv 1

I don't know what is / I did wrong, but I designed a fold - perfectly fine, but after a while I wiggled, and one part of the protein will start to unfold (the helix is not a helix anymore) and the score goes down instead of up.
I sent the structure to scientists - if you could reproduce that behavior would be interesting! :)