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Protein Design Sandbox

Closed since almost 4 years ago

Beginner

Summary

Created
March 22, 2020
Expires
Max points
100
Description

Experiment with protein design! We've disabled many of the restrictions in normal Science puzzles, so players have access to all protein designs tools, and may insert and delete any number of residues. Foldit scientists do not check the solutions from this puzzle, and playing this puzzle will not affect your global or category rankings.



Two common protein design Objectives are available, but they will not award any bonuses or penalties. The Core Existence Objective checks to see if 30% of residues are buried in the protein core, away from the water surrounding the protein. The Ideal Loops Objective looks for loops with problematic backbone folds. If you build an especially large protein, try disabling these Objectives to improve Foldit's performance.

Top groups

  1. Avatar for Anthropic Dreams
    1. Anthropic Dreams
    100 pts. 46,086
  2. Avatar for Contenders 2. Contenders 95 pts. 40,014
  3. Avatar for Gargleblasters 3. Gargleblasters 90 pts. 37,120
  4. Avatar for Beta Folders 4. Beta Folders 84 pts. 32,500
  5. Avatar for BOINC@Poland 5. BOINC@Poland 80 pts. 29,493
  6. Avatar for Team China 6. Team China 75 pts. 29,032
  7. Avatar for Go Science 7. Go Science 70 pts. 25,493
  8. Avatar for Russian team 8. Russian team 66 pts. 25,114
  9. Avatar for Australia 9. Australia 62 pts. 22,809
  10. Avatar for Penny-Arcade 10. Penny-Arcade 58 pts. 22,049
  1. Avatar for Lunatik4872 1021. Lunatik4872 Lv 1 1 pt. 2,083
  2. Avatar for sblee418 1022. sblee418 Lv 1 1 pt. 2,081
  3. Avatar for LittleRibosome 1023. LittleRibosome Lv 1 1 pt. 2,052
  4. Avatar for 34toco 1024. 34toco Lv 1 1 pt. 2,049
  5. Avatar for Dwells 1025. Dwells Lv 1 1 pt. 2,030
  6. Avatar for lynx5864 1026. lynx5864 Lv 1 1 pt. 2,015
  7. Avatar for SamLewis 1027. SamLewis Lv 1 1 pt. 1,935
  8. Avatar for Misch2k 1028. Misch2k Lv 1 1 pt. 1,932
  9. Avatar for zen-o-morph 1029. zen-o-morph Lv 1 1 pt. 1,906
  10. Avatar for prooh 1030. prooh Lv 1 1 pt. 1,890

Comments

DoctorSockrates Lv 1

I was wondering when something like this would turn up. Glad to see an unrestricted proving ground for future projects.

KALYPSO Lv 1

Soap,,,,breaks the faty around the cell ,,,hmmmmm,,,puzzle that,,,just saying,,,try it

Bautho Lv 1

I don't know what is / I did wrong, but I designed a fold - perfectly fine, but after a while I wiggled, and one part of the protein will start to unfold (the helix is not a helix anymore) and the score goes down instead of up.
I sent the structure to scientists - if you could reproduce that behavior would be interesting! :)