Placeholder image of a protein
Icon representing a puzzle

Protein Design Sandbox

Closed since about 4 years ago

Beginner

Summary

Created
March 22, 2020
Expires
Max points
100
Description

Experiment with protein design! We've disabled many of the restrictions in normal Science puzzles, so players have access to all protein designs tools, and may insert and delete any number of residues. Foldit scientists do not check the solutions from this puzzle, and playing this puzzle will not affect your global or category rankings.



Two common protein design Objectives are available, but they will not award any bonuses or penalties. The Core Existence Objective checks to see if 30% of residues are buried in the protein core, away from the water surrounding the protein. The Ideal Loops Objective looks for loops with problematic backbone folds. If you build an especially large protein, try disabling these Objectives to improve Foldit's performance.

Top groups

  1. Avatar for Anthropic Dreams
    1. Anthropic Dreams
    100 pts. 46,086
  2. Avatar for Contenders 2. Contenders 95 pts. 40,014
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  4. Avatar for Beta Folders 4. Beta Folders 84 pts. 32,500
  5. Avatar for BOINC@Poland 5. BOINC@Poland 80 pts. 29,493
  6. Avatar for Team China 6. Team China 75 pts. 29,032
  7. Avatar for Go Science 7. Go Science 70 pts. 25,493
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  10. Avatar for Penny-Arcade 10. Penny-Arcade 58 pts. 22,049
  1. Avatar for tomstueve 901. tomstueve Lv 1 2 pts. 2,566
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  3. Avatar for Tyler4Jacobson 903. Tyler4Jacobson Lv 1 2 pts. 2,565
  4. Avatar for Edwardinsnow 904. Edwardinsnow Lv 1 2 pts. 2,565
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  7. Avatar for Ben2010 907. Ben2010 Lv 1 2 pts. 2,560
  8. Avatar for Tal Z Honig 908. Tal Z Honig Lv 1 2 pts. 2,560
  9. Avatar for RichardGossens 909. RichardGossens Lv 1 2 pts. 2,558
  10. Avatar for Lil_Void 910. Lil_Void Lv 1 2 pts. 2,555

Comments

DoctorSockrates Lv 1

I was wondering when something like this would turn up. Glad to see an unrestricted proving ground for future projects.

KALYPSO Lv 1

Soap,,,,breaks the faty around the cell ,,,hmmmmm,,,puzzle that,,,just saying,,,try it

Bautho Lv 1

I don't know what is / I did wrong, but I designed a fold - perfectly fine, but after a while I wiggled, and one part of the protein will start to unfold (the helix is not a helix anymore) and the score goes down instead of up.
I sent the structure to scientists - if you could reproduce that behavior would be interesting! :)