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1820: Coronavirus ORF8 Prediction

Closed since about 6 years ago

Intermediate Overall Prediction

Summary

Created
April 01, 2020
Expires
Max points
100
Description

Fold this coronavirus protein! This protein is encoded in the viral genome of SARS-CoV-2, in a region called ORF8, but the protein's structure is still unknown. Evidence suggests this protein triggers a stress signal in the infected cell. If we knew how this protein folds, we might be able to figure out its exact function. The puzzle's starting structure shows SS predictions from PSIPRED, and hints which parts of the protein might fold into helices or sheets. Refold this protein to find high-scoring solutions, which will tell us how this protein is most likely to fold!



Sequence:


MKFLVFLGIITTVAAFHQECSLQSCTQHQPYVVDDPCPIHFYSKWYIRVGARKSAPLIELCVDEAGSKSPIQYIDIGNYTVSCLPFTINCQEPKLGSLVVRCSFYEDFLEYHDVRVVLDFI

Top groups

  1. Avatar for Star Fleet Academy Sciences Division 31. Star Fleet Academy Sciences Division 1 pt. 0
  2. Avatar for SHELL 32. SHELL 1 pt. 0
  3. Avatar for Foldit_SaintJohn(NB) 33. Foldit_SaintJohn(NB) 1 pt. 0
  4. Avatar for Russian team 34. Russian team 1 pt. 0
  5. Avatar for Team India 35. Team India 1 pt. 0
  1. Avatar for zeroblue 31. zeroblue Lv 1 79 pts. 10,018
  2. Avatar for Blipperman 32. Blipperman Lv 1 78 pts. 10,017
  3. Avatar for Phyx 33. Phyx Lv 1 78 pts. 9,993
  4. Avatar for Skippysk8s 34. Skippysk8s Lv 1 77 pts. 9,948
  5. Avatar for anthion 35. anthion Lv 1 76 pts. 9,921
  6. Avatar for malthreSC 36. malthreSC Lv 1 76 pts. 9,920
  7. Avatar for mat747 37. mat747 Lv 1 75 pts. 9,916
  8. Avatar for g_b 38. g_b Lv 1 74 pts. 9,879
  9. Avatar for spdenne 39. spdenne Lv 1 74 pts. 9,875
  10. Avatar for crpainter 40. crpainter Lv 1 73 pts. 9,867

Comments

Serca Lv 1

Some idea for design for that structures:

But it has a lot of exposed hydrophobic segments. So if it is not a membrane protein (but it could be because of the long helix), it doesn't hit the good score.

aofreelancer Lv 1

I do work at this puzzle two, i was able to fold it, but i have no biology science background was kind off thrown away by the complexity of it.