Placeholder image of a protein
Icon representing a puzzle

1835: Coronavirus NSP2 Prediction

Closed since almost 6 years ago

Intermediate Overall Prediction

Summary

Created
May 07, 2020
Expires
Max points
100
Description

Fold this coronavirus protein! This is one portion of a larger protein encoded in the viral genome of SARS-CoV-2. It is encoded in a region of the genome called NSP2, but the protein's structure and function are still unknown. If we knew how this protein folds, we might be able to figure out its exact function. The puzzle's starting structure shows SS predictions from PSIPRED, and hints which parts of the protein might fold into helices or sheets. Refold this protein to find high-scoring solutions, which will tell us how this protein is most likely to fold!



Sequence:


AARVVRSIFSRTLETAQNSVRVLQKAAITILDGISQYSLRLIDAMMFTSDLATNNLVVMAYITGGVVQLTSQWLTNIFGTVYEKLKPVLDWLEEKFKEGVEFLRDGWEIVKFISTCACEIVGGQIVTCAKEIKESVQTFF

Top groups

  1. Avatar for BOINC@Poland 11. BOINC@Poland 7 pts. 11,037
  2. Avatar for Chem Eng Thermo 12. Chem Eng Thermo 5 pts. 10,766
  3. Avatar for Penny-Arcade 13. Penny-Arcade 4 pts. 10,644
  4. Avatar for Rechenkraft.net 14. Rechenkraft.net 3 pts. 10,113
  5. Avatar for FoldIt@Netherlands 15. FoldIt@Netherlands 2 pts. 9,988
  6. Avatar for SETI.Germany 16. SETI.Germany 1 pt. 9,455
  7. Avatar for Russian team 17. Russian team 1 pt. 8,941
  8. Avatar for Team China 18. Team China 1 pt. 8,113
  9. Avatar for CHNO Junkies 19. CHNO Junkies 1 pt. 7,310
  10. Avatar for Team South Africa 20. Team South Africa 1 pt. 6,625
  1. Avatar for GVA123 311. GVA123 Lv 1 1 pt. 3,657
  2. Avatar for TillyH 312. TillyH Lv 1 1 pt. 3,654
  3. Avatar for boondog 313. boondog Lv 1 1 pt. 3,347
  4. Avatar for micon 314. micon Lv 1 1 pt. 3,297
  5. Avatar for 3rdwave 315. 3rdwave Lv 1 1 pt. 3,181
  6. Avatar for tombickle 316. tombickle Lv 1 1 pt. 3,113
  7. Avatar for deathbat_87 317. deathbat_87 Lv 1 1 pt. 3,053
  8. Avatar for Prateek_vikram42 318. Prateek_vikram42 Lv 1 1 pt. 3,013
  9. Avatar for elblacula 319. elblacula Lv 1 1 pt. 2,938
  10. Avatar for Yobu 320. Yobu Lv 1 1 pt. 2,798

Comments

Steven Pletsch Lv 1

I ran my own psipred prediction on this. Only place it varies significantly is that it predicted the small helix to just as likely be a sheet, so I stripped color from any segments that had a low confidence and converted the small helix to a sheet, making a small sheet pair with cysteine at the end of each. Though I haven't been able to get a disulfide bond that keeps the score up, it puts all 3 cysteine together in the same small pocket.