Placeholder image of a protein
Icon representing a puzzle

1835: Coronavirus NSP2 Prediction

Closed since almost 6 years ago

Intermediate Overall Prediction

Summary

Created
May 07, 2020
Expires
Max points
100
Description

Fold this coronavirus protein! This is one portion of a larger protein encoded in the viral genome of SARS-CoV-2. It is encoded in a region of the genome called NSP2, but the protein's structure and function are still unknown. If we knew how this protein folds, we might be able to figure out its exact function. The puzzle's starting structure shows SS predictions from PSIPRED, and hints which parts of the protein might fold into helices or sheets. Refold this protein to find high-scoring solutions, which will tell us how this protein is most likely to fold!



Sequence:


AARVVRSIFSRTLETAQNSVRVLQKAAITILDGISQYSLRLIDAMMFTSDLATNNLVVMAYITGGVVQLTSQWLTNIFGTVYEKLKPVLDWLEEKFKEGVEFLRDGWEIVKFISTCACEIVGGQIVTCAKEIKESVQTFF

Top groups

  1. Avatar for Hold My Beer
    1. Hold My Beer
    100 pts. 11,576
  2. Avatar for Gargleblasters 2. Gargleblasters 81 pts. 11,374
  3. Avatar for Go Science 3. Go Science 65 pts. 11,358
  4. Avatar for Team India 4. Team India 52 pts. 11,325
  5. Avatar for Marvin's bunch 5. Marvin's bunch 41 pts. 11,303
  6. Avatar for Beta Folders 6. Beta Folders 32 pts. 11,219
  7. Avatar for Contenders 7. Contenders 24 pts. 11,197
  8. Avatar for Anthropic Dreams 8. Anthropic Dreams 18 pts. 11,189
  9. Avatar for Void Crushers 9. Void Crushers 14 pts. 11,155
  10. Avatar for L'Alliance Francophone 10. L'Alliance Francophone 10 pts. 11,124
  1. Avatar for Loungin001 351. Loungin001 Lv 1 1 pt. 0
  2. Avatar for 01010011111 352. 01010011111 Lv 1 1 pt. 0
  3. Avatar for hakanylmaz 353. hakanylmaz Lv 1 1 pt. 0
  4. Avatar for Slense 354. Slense Lv 1 1 pt. 0
  5. Avatar for firebulldogs 355. firebulldogs Lv 1 1 pt. 0
  6. Avatar for kvasirthewise 356. kvasirthewise Lv 1 1 pt. 0
  7. Avatar for JMStiffler 357. JMStiffler Lv 1 1 pt. 0
  8. Avatar for apu204 358. apu204 Lv 1 1 pt. 0
  9. Avatar for Aromero13 359. Aromero13 Lv 1 1 pt. 0
  10. Avatar for Fuad Agaev 360. Fuad Agaev Lv 1 1 pt. 0

Comments

Steven Pletsch Lv 1

I ran my own psipred prediction on this. Only place it varies significantly is that it predicted the small helix to just as likely be a sheet, so I stripped color from any segments that had a low confidence and converted the small helix to a sheet, making a small sheet pair with cysteine at the end of each. Though I haven't been able to get a disulfide bond that keeps the score up, it puts all 3 cysteine together in the same small pocket.