Placeholder image of a protein
Icon representing a puzzle

LCB1 Coronavirus Spike Binder

Closed since over 5 years ago

Novice

Summary

Created
August 30, 2020
Expires
Max points
100
Description

Note: This puzzle had some incorrect settings for Core Exists, Ideal Loops, and SS Design Objectives. It has been replaced with an updated LCB1 puzzle.



This is a non-competitive "sandbox" puzzle where you can explore a protein designed by IPD scientists. The starting structure is LCB1, a designed protein that binds to the coronavirus spike protein to block viral infection. This design was just one of millions of proteins designed by researchers. It was chosen for testing because it has excellent binder metrics. Lab tests have shown that this binder can potently inhibit viral infection in a test tube, but further tests are needed to determine safety and efficacy in animals.

Top groups

  1. Avatar for SETI.Germany
    1. SETI.Germany
    100 pts. 12,217
  2. Avatar for L'Alliance Francophone 2. L'Alliance Francophone 65 pts. 12,179
  3. Avatar for Gargleblasters 3. Gargleblasters 41 pts. 12,135
  4. Avatar for Go Science 4. Go Science 24 pts. 12,110
  5. Avatar for BOINC@Poland 5. BOINC@Poland 14 pts. 12,110
  6. Avatar for Contenders 6. Contenders 7 pts. 12,108
  7. Avatar for Anthropic Dreams 7. Anthropic Dreams 4 pts. 12,051
  8. Avatar for Hold My Beer 8. Hold My Beer 2 pts. 11,906
  9. Avatar for Team Canada 9. Team Canada 1 pt. 11,800
  10. Avatar for Team South Africa 10. Team South Africa 1 pt. 11,660
  1. Avatar for Ashrai 21. Ashrai Lv 1 4 pts. 11,773
  2. Avatar for TastyMunchies 22. TastyMunchies Lv 1 4 pts. 11,753
  3. Avatar for rezaefar 23. rezaefar Lv 1 3 pts. 11,745
  4. Avatar for CharlieFortsConscience 24. CharlieFortsConscience Lv 1 2 pts. 11,715
  5. Avatar for Formula350 25. Formula350 Lv 1 2 pts. 11,667
  6. Avatar for abiogenesis 26. abiogenesis Lv 1 2 pts. 11,664
  7. Avatar for doctaven 27. doctaven Lv 1 1 pt. 11,660
  8. Avatar for Todd6485577 28. Todd6485577 Lv 1 1 pt. 11,596
  9. Avatar for silent gene 29. silent gene Lv 1 1 pt. 11,564
  10. Avatar for APPAAP 30. APPAAP Lv 1 1 pt. 11,559

Comments

Bruno Kestemont Lv 1

It starts with very bad score and filter passings. Actually, it(s the target that is scoring bad filters.
What do you mean by a "promizing design by scintists"? Is it the secondary sructure? the primary structure ? the position on the binding site ?

Formula350 Lv 1

Here's the link tot he pre-print paper on LCB1 and LCB3. It's all greek to me, but perhaps it'll assist those of you with more BioChem knowledge in determining the answer to that question. :)

(99% certain this is the same paper that was linked to in the latest blog post, which that post also provides a bit of info on LCB1, so reading the entire publication may not be needed?)