Beginner Puzzle (<150): Docking Design

Closed since over 5 years ago

Summary

• Created: January 27, 2014
• Expires: October 29, 2020 at 23:00 UTC
• Max points: 100

Description

We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.



START HERE:

If you are new to Foldit, here are detailed instructions to get you started:

http://fold.it/portal/node/988864

_____________________________

If you want to fold proteins, know that there are many ways to play and this variety is the main value of Foldit :

- try all puzzles not only "Beginners" ones,

- fold first the ones you like the most,

- try it by yourself to understand what works and what doesn't,

- ask for tips in global chat when you think you don't understand something.

Make sure you have followed these tutorials:

- Lonely Sheets,

- Lock and Lower,

- Rebuild,

- Structure and Rebuild,

- Movin' Along,

- Control over Clashing,

- Intro to Design,

- Swappin' Sidechains,

- Mass Mutate,

- Insertion and Deletion

before starting this puzzle.

Top groups

• 1. Anthropic Dreams 100 pts. 10,382
• 2. Void Crushers 84 pts. 10,242
• 3. Mercer_F20_BMB465_Crawford 70 pts. 10,240
• 4. Deleted group pts. 10,220
• 5. MAB_STEM 47 pts. 10,216
• 6. CH362_ButlerUniversity 38 pts. 10,176
• 7. Team China 30 pts. 10,139
• 8. Go Science 24 pts. 10,108
• 9. practice 19 pts. 10,105
• 10. Deleted group pts. 10,087

Top soloists

• 161. Ramponis 12 pts. 10,034
• 162. d21dan 12 pts. 10,032
• 163. Gmoney17 12 pts. 10,032
• 164. yuwei8129 12 pts. 10,031
• 165. Dipesh_P 12 pts. 10,028
• 166. Fawal2895 11 pts. 10,025
• 167. morgan_mathis 11 pts. 10,025
• 168. mad.bees 11 pts. 10,020
• 169. ncurrao 11 pts. 10,015
• 170. josev 11 pts. 10,003