Beginner Puzzle (<150): Docking Design

Closed since over 5 years ago

Summary

• Created: January 27, 2014
• Expires: October 29, 2020 at 23:00 UTC
• Max points: 100

Description

We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.



START HERE:

If you are new to Foldit, here are detailed instructions to get you started:

http://fold.it/portal/node/988864

_____________________________

If you want to fold proteins, know that there are many ways to play and this variety is the main value of Foldit :

- try all puzzles not only "Beginners" ones,

- fold first the ones you like the most,

- try it by yourself to understand what works and what doesn't,

- ask for tips in global chat when you think you don't understand something.

Make sure you have followed these tutorials:

- Lonely Sheets,

- Lock and Lower,

- Rebuild,

- Structure and Rebuild,

- Movin' Along,

- Control over Clashing,

- Intro to Design,

- Swappin' Sidechains,

- Mass Mutate,

- Insertion and Deletion

before starting this puzzle.

Top groups

• 1. Anthropic Dreams 100 pts. 10,382
• 2. Void Crushers 84 pts. 10,242
• 3. Mercer_F20_BMB465_Crawford 70 pts. 10,240
• 4. Deleted group pts. 10,220
• 5. MAB_STEM 47 pts. 10,216
• 6. CH362_ButlerUniversity 38 pts. 10,176
• 7. Team China 30 pts. 10,139
• 8. Go Science 24 pts. 10,108
• 9. practice 19 pts. 10,105
• 10. Deleted group pts. 10,087

Top soloists

• 21. John_L 81 pts. 10,228
• 22. jennyyu34 80 pts. 10,226
• 23. akaaka 79 pts. 10,224
• 24. _MATH KING 78 pts. 10,224
• 25. colbywilliams25 77 pts. 10,223
• 26. Zack13 76 pts. 10,222
• 27. Brenton_P 75 pts. 10,220
• 28. Jrei9278 74 pts. 10,217
• 29. Adam Wolowczyk 74 pts. 10,217
• 30. vfinn 73 pts. 10,216