Beginner Puzzle (<150): Docking Design

Closed since almost 5 years ago

Summary

• Created: January 27, 2014
• Expires: March 25, 2021 at 23:00 UTC
• Max points: 100

Description

We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.



START HERE:

If you are new to Foldit, here are detailed instructions to get you started:

http://fold.it/portal/node/988864

_____________________________

If you want to fold proteins, know that there are many ways to play and this variety is the main value of Foldit :

- try all puzzles not only "Beginners" ones,

- fold first the ones you like the most,

- try it by yourself to understand what works and what doesn't,

- ask for tips in global chat when you think you don't understand something.

Make sure you have followed these tutorials:

- Lonely Sheets,

- Lock and Lower,

- Rebuild,

- Structure and Rebuild,

- Movin' Along,

- Control over Clashing,

- Intro to Design,

- Swappin' Sidechains,

- Mass Mutate,

- Insertion and Deletion

before starting this puzzle.

Top groups

• 1. Czech National Team 100 pts. 10,315
• 2. Go Science 76 pts. 10,269
• 3. Deleted group pts. 10,238
• 4. Coastal Biochemistry 41 pts. 10,208
• 5. CHM 232 Lab GVSU 29 pts. 10,095
• 6. Chemistry 323 F2016 20 pts. 9,957
• 7. Wright Biology SBI4U 14 pts. 9,949
• 8. SHELL 9 pts. 9,901
• 9. Otterbein Cell Biology 2021 6 pts. 9,872
• 10. BIOCHEM 3Z03 Winter 2021 1 4 pts. 9,845

Top soloists

• 31. sahas-and-sahana 27 pts. 10,193
• 32. morlando89 26 pts. 10,187
• 33. fabzs1 25 pts. 10,174
• 34. standia 23 pts. 10,174
• 35. titans 22 pts. 10,156
• 36. yousafh 21 pts. 10,141
• 37. Swapper242 20 pts. 10,136
• 38. nebs 19 pts. 10,135
• 39. 81189h 18 pts. 10,132
• 40. HCresF 17 pts. 10,130