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Design of the Month: April 2021

Closed since almost 5 years ago

Intermediate

Summary

Created
March 31, 2021
Expires
Max points
100
Description

This sandbox puzzle features three solutions submitted by LociOiling for our Influenza HA Binder Design Competition. Reset the puzzle to cycle through the three different designs. All of these designed binders look like they have a good chance of folding correctly, and orange hydrophobic residues at the target interface will make for tight binding. Look out for blue polar sidechains on the target that are buried by the binder; if the binder does not make H-bonds with the polar atoms on these sidechains, they will become unstable BUNS and prevent binding! For more, check out Foldit Lab Report #19 on YouTube! This sandbox puzzle is non-competitive and will not award any points.

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