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Design of the Month: July 2021

Closed since over 4 years ago

Intermediate

Summary

Created
July 01, 2021
Expires
Max points
100
Description

This sandbox puzzle features a D2 symmetric design, created by an anonymous player in Puzzle 1998. The monomer subunit takes on an unusual fold that has two beta-sheets, each of which creates a distinct interface with other symmetric subunits! The monomer subunit has a lot of hydrophobic surface area, which may spell trouble for proper folding; but if it does fold and assemble correctly, we would expect extremely tight binding between subunits. For more, check out Foldit Lab Report #22 on YouTube! This sandbox puzzle is non-competitive and will not award any points.



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Comments

mwm64 Lv 1

I just now filled out the form so you can mention me :-)

The idea was that that you can make a pattern of hydrophobics and polars on the outside of one sheet, and make a matching one (mirrored, rotated 90 degrees, and reversing polarities) on the other sheet so they match up. It turned out to not be quite that easy (the grids aren't quite square, etc.) but that was the idea.