Beginner Puzzle (<150): Docking Design

Closed since about 4 years ago

Summary

• Created: January 27, 2014
• Expires: January 13, 2022 at 23:00 UTC
• Max points: 100

Description

We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.



START HERE:

If you are new to Foldit, here are detailed instructions to get you started:

http://fold.it/portal/node/988864

_____________________________

If you want to fold proteins, know that there are many ways to play and this variety is the main value of Foldit :

- try all puzzles not only "Beginners" ones,

- fold first the ones you like the most,

- try it by yourself to understand what works and what doesn't,

- ask for tips in global chat when you think you don't understand something.

Make sure you have followed these tutorials:

- Lonely Sheets,

- Lock and Lower,

- Rebuild,

- Structure and Rebuild,

- Movin' Along,

- Control over Clashing,

- Intro to Design,

- Swappin' Sidechains,

- Mass Mutate,

- Insertion and Deletion

before starting this puzzle.

Top groups

• 1. Italiani Al Lavoro 100 pts. 10,333
• 2. foldeRNA 47 pts. 10,222
• 3. Gargleblasters 19 pts. 10,055
• 4. StueveBio 7 pts. 10,053
• 5. pikem125 2 pts. 9,944
• 6. Anthropic Dreams 1 pt. 9,809
• 7. Coastal Biochemistry 1 pt. 8,220
• 8. Foldit Staff 1 pt. 8,149

Top soloists

• 41. jaegipto 1 pt. 9,944
• 42. i.lotsaris 1 pt. 9,913
• 43. nicemalo 1 pt. 9,847
• 44. ken_663 1 pt. 9,845
• 45. harvardman 1 pt. 9,809
• 46. drleighphd 1 pt. 9,809
• 47. markoan 1 pt. 9,809
• 48. einar palisoc 1 pt. 9,767
• 49. Kallian90 1 pt. 9,749
• 50. kminjin999 1 pt. 9,529