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2266: Electron Density Reconstruction 27

Closed since about 3 years ago

Novice Overall Prediction Electron Density

Summary

Created
February 07, 2023
Expires
Max points
100
Description

The structure of this protein has already been solved and published, but close inspection suggests that there are some problems with the published solution. We'd like to see if Foldit players can use the same electron density data to reconstruct a better model.

Sequence
MDETGKELVLVLYDYQEKSPREVTIKKGDILTLLNSTNKDWWKIEVNDRQGFVPAAYLKKLD

Top groups

  1. Avatar for Go Science
    1. Go Science
    100 pts. 16,327
  2. Avatar for Anthropic Dreams 2. Anthropic Dreams 68 pts. 16,324
  3. Avatar for Contenders 3. Contenders 44 pts. 16,298
  4. Avatar for Void Crushers 4. Void Crushers 27 pts. 16,294
  5. Avatar for FamilyBarmettler 5. FamilyBarmettler 16 pts. 16,269
  6. Avatar for Gargleblasters 6. Gargleblasters 9 pts. 16,251
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  9. Avatar for Australia 9. Australia 1 pt. 16,203
  10. Avatar for Marvin's bunch 10. Marvin's bunch 1 pt. 16,137
  1. Avatar for rezaefar 61. rezaefar Lv 1 1 pt. 15,899
  2. Avatar for Deleted player 62. Deleted player 1 pt. 15,893
  3. Avatar for rosie4loop 63. rosie4loop Lv 1 1 pt. 15,890
  4. Avatar for Jackd4w 64. Jackd4w Lv 1 1 pt. 15,879
  5. Avatar for Dr.Sillem 65. Dr.Sillem Lv 1 1 pt. 15,876
  6. Avatar for rinze 66. rinze Lv 1 1 pt. 15,869
  7. Avatar for B. A. Beder 67. B. A. Beder Lv 1 1 pt. 15,842
  8. Avatar for Merf 68. Merf Lv 1 1 pt. 15,838
  9. Avatar for Swapper242 69. Swapper242 Lv 1 1 pt. 15,838
  10. Avatar for DScott 70. DScott Lv 1 1 pt. 15,837

Comments

grogar7 Lv 1

Tell us more about the little dot that identifies as residue #1 Glycine, and is not attached to the rest of the protein?

LociOiling Lv 1

Weird, a solution loaded at 2,292 after being saved at 15,893. The 2292 killed a version of DRemix that's been working a long time. Not sure what's wrong with this one.

LociOiling Lv 1

Shared with scientists, a second one saved on 15,893, which loads at 2,298. The damaged load also manages to break some fancy Lua code related to getting the density score for a section. Regular old DRemix doesn't have that problem.

LociOiling Lv 1

See more comments in #bugs-and-feedback. The damaged solutions end up with around -3,000 ideality in 4 segments, totalling up to a roughly 13,000 point loss.

LociOiling Lv 1

See also https://fold.it/forum/bugs/saved-solutions-for-puzzle-2266-lose-score

The sequence is a another mystery here. The sequence shown on this page is an exact match for PDB 1E6H.

The puzzle starts with G for glycine in segement 1. The puzzle shows segment 1 as just a small sphere, not a normal-looking segment at all.

The puzzle ended up with gaps between 1-2 and 31-32. So the alignment ends up looking like this:

mdetgkelvlvlydyqeksprevtikkgdiltllnstnkdwwkievndrqgfvpaaylkkld (1E6H)
    g elvlvlydyqeksprevtikkgdiltllns nkdwwkievndrqgfvpaaylkkld (puzzle 2262)
    1 234567890123456789012345678901 2345678901234567890123456
              1         2         3          4         5

The two gaps in the sequence seem to be the source of the problem with saved solutions.